ArticleMolecules (Basel, Switzerland)2020
Polydopamine Nanosphere with In-Situ Loaded Gentamicin and Its Antimicrobial Activity.
Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Conjugated biopolymer assisted separation of nanoplastics from aqueous systems: a step towards sustainability.RSC advances · 2026Article
- Soft Hypoxia-Adaptive Bioelectronics Integrating PEDOT:PSS/Polydopamine/Enzyme Biocomposites for Closed-Loop Therapeutics of Chronic Wounds.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Bacterial Nanocellulose Wound Dressings with Gentamicin-Loaded Chitosan Nanoparticles for Surgical Site Infection Management.Polymers · 2026Article
- An Injectable Hybrid Gelatin Methacryloyl/Polydopamine Nanoparticle Bioink for Rapid Hemostasis Applications.ACS applied bio materials · 2026Article
- Article
- Injectable Self-Polymerizing Hydrogel as Bone Filler for Bone Defect Treatment.Macromolecular bioscience · 2025Article
- PDA-integrated Au@Ag with colorimetric/SERS dual-signal enhancement capability for flexible lateral flow immunoassay detection of respiratory viruses.Mikrochimica acta · 2025Article
- Nanotechnology Meets superbugs: biocompatible polymeric nanoparticles combat MDR Klebsiella pneumoniae via gene suppression and biofilm Inhibition.Scientific reports · 2025Article
- Bioinspired Nanoplatforms: Polydopamine and Exosomes for Targeted Antimicrobial Therapy.Polymers · 2025Review
- Regenerable Poly(dopamine)-Mediated Gold Nanostructure-Decorated Core-Shell Nanostructures of Magnetite/Polydopamine for Catalytic Dye Removal.ACS omega · 2024Article
- Mesoporous Polydopamine Nano-Bowls Demonstrate a High Entrapment Efficiency and pH-Responsive Release of Paclitaxel for Suppressing A549 Lung Cancer Cell Proliferation In Vitro.Pharmaceutics · 2024Article
- Enhancing Gentamicin Antibacterial Activity by Co-Encapsulation with Thymoquinone in Liposomal Formulation.Pharmaceutics · 2024Article
- Biomimicking trilayer scaffolds with controlled estradiol release for uterine tissue regeneration.Exploration (Beijing, China) · 2024Article
- Comparative performance analysis of mussel-inspired polydopamine, polynorepinephrine, and poly-α-methyl norepinephrine in electrochemical biosensors.Mikrochimica acta · 2024Article
- Effect of Gentamicin Sulfate and Polymeric Polyethylene Glycol Coating on the Degradation and Cytotoxicity of Iron-Based Biomaterials.ACS omega · 2024Article
- Design and Application of Microfluidic Capture Device for Physical-Magnetic Isolation of MCF-7 Circulating Tumor Cells.Biosensors · 2024Article
- Mesoscale size-promoted targeted therapy for acute kidney injury through combined RONS scavenging and inflammation alleviation strategy.Materials today. Bio · 2024Article
- Controlled Nitric Oxide-Releasing Nanovehicles for Enhanced Infected Wound Healing: A Study on PDA@BNN6 Encapsulated in GelMA Hydrogel.International journal of nanomedicine · 2024Article
- Fimbria targeting superparamagnetic iron oxide nanoparticles enhance the antimicrobial and antibiofilm activity of ciprofloxacin against quinolone-resistant E. coli.Microbial biotechnology · 2023Article
- Facile synthesis of gold nanocages with silver nanocubes templates dual metal effects enabled SERS imaging and catalytic reduction.RSC advances · 2023Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mussel inspired polydopamine has acquired great relevance in the field of nanomedicines, owing to its incredible physicochemical properties. Polydopamine nanoparticles (PDA NPs) due to their low cytotoxicity, high biocompatibility and ready biodegradation have already been widely investigated in various drug delivery, chemotherapeutic, and diagnostic applications. In addition, owing to its highly reactive nature, it possesses a very high capability for loading drugs and chemotherapeutics. Therefore, the loading efficiency of PDA NPs for an antibiotic i.e., gentamicin (G) has been investigated in this work. For this purpose, an in-situ polymerization method was studied to load the drug into PDA NPs using variable drug: monomer ratios. Scanning electron microscope (SEM), Fourier-transform infrared spectroscopy (FTIR), and X-ray photoelectron spectroscopy (XPS) confirmed the successful loading of drug within PDA NPs, mainly via hydrogen bonding between the amine groups of gentamicin and the hydroxyl groups of PDA. The loading amount was quantified by liquid chromatography-mass spectrometry (LC-MS) and the highest percentage loading capacity was achieved for G-PDA prepared with drug to monomer ratio of 1:1. Moreover, the gentamicin loaded PDA NPs were tested in a preliminary antibacterial evaluation using the broth microdilution method against both Gram-(+)
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.