Evidence map›Paper›PMID 32365632›Full record

ArticleCells2020

L-Selectin/CD62L is a Key Driver of Non-Alcoholic Steatohepatitis in Mice and Men.

Hannah K Drescher, Angela Schippers, Stefanie Rosenhain, Felix Gremse, Laura Bongiovanni, Alain de Bruin, Sreepradha Eswaran, Suchira U Gallage, Dominik Pfister, Marta Szydlowska and 6 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 25 citations in OpenAlex.

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  6. Review
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  9. Article
  10. Sinusoidal endotheliopathy in nonalcoholic steatohepatitis: therapeutic implications.American journal of physiology. Gastrointestinal and liver physiology · 2021
    Review
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 3 countries.

Hannah K DrescherDepartment of Internal Medicine III, University Hospital, 52074 RWTH Aachen, Germany.
Angela SchippersDepartment of Pediatrics, University Hospital, 52074 RWTH Aachen, Germany.
Stefanie RosenhainInstitute for Experimental Molecular Imaging, University Hospital, 52074 RWTH Aachen University, Germany.
Felix GremseInstitute for Experimental Molecular Imaging, University Hospital, 52074 RWTH Aachen University, Germany.
Laura BongiovanniDutch Molecular Pathology Centre, Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, 3512 Utrecht, The Netherlands.
Alain de BruinDutch Molecular Pathology Centre, Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, 3512 Utrecht, The Netherlands.
Sreepradha EswaranDepartment of Pediatrics, University Hospital, 52074 RWTH Aachen, Germany.
Suchira U GallageDivision of Chronic Inflammation and Cancer, German Cancer Research Center Heidelberg (DKFZ), 69120 Heidelberg, Germany.
Dominik PfisterDivision of Chronic Inflammation and Cancer, German Cancer Research Center Heidelberg (DKFZ), 69120 Heidelberg, Germany.
Marta SzydlowskaDivision of Chronic Inflammation and Cancer, German Cancer Research Center Heidelberg (DKFZ), 69120 Heidelberg, Germany.
Mathias HeikenwalderDivision of Chronic Inflammation and Cancer, German Cancer Research Center Heidelberg (DKFZ), 69120 Heidelberg, Germany.
Sabine WeiskirchenInstitute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), University Hospital, RWTH Aachen University, 52074 Aachen, Germany.
Norbert WagnerDepartment of Pediatrics, University Hospital, 52074 RWTH Aachen, Germany.
Christian TrautweinDepartment of Internal Medicine III, University Hospital, 52074 RWTH Aachen, Germany.
Ralf WeiskirchenInstitute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), University Hospital, RWTH Aachen University, 52074 Aachen, Germany.
Daniela C KroyDepartment of Internal Medicine III, University Hospital, 52074 RWTH Aachen, Germany.
RWTH Aachen University · DEGerman Cancer Research Center · DEUtrecht University · NLHarvard University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CD62L (L-Selectin) dependent lymphocyte infiltration is known to induce inflammatory bowel disease (IBD), while its function in the liver, especially in non-alcoholic steatohepatitis (NASH), remains unclear. We here investigated the functional role of CD62L in NASH in humans as well as in two mouse models of steatohepatitis. Hepatic expression of a soluble form of CD62L (sCD62L) was measured in patients with steatosis and NASH. Furthermore, CD62L

Indexed as

AnimalsCells, CulturedDiet, High-FatDisease Models, AnimalHepatocytesHumansLiverL-SelectinMaleMice, Inbred C57BLNon-alcoholic Fatty Liver DiseaseL-SelectinCD62Linsulin resistanceL-SelectinNASHnon-alcoholic steatohepatitis

Identifiers

PMID32365632
PMCPMC7290433
OpenAlexW3021772844

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.