Evidence map›Paper›PMID 32365611›Full record

ArticleMicroorganisms2020

Lipocalin2 Induced by Bacterial Flagellin Protects Mice against Cyclophosphamide Mediated Neutropenic Sepsis.

Daejin Lim, Hee Kyung Kim, Jae-Ho Jeong, Yoon Seok Jung, Shee Eun Lee, Hee-Chang Jang, Sook-In Jung, Hueng-Sik Choi, Joon Haeng Rhee, Sung-Gwon Lee and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microorganisms, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Daejin LimDepartment of Microbiology, Chonnam National University Medical School, Gwangju 61468, Korea.
Hee Kyung KimDepartment of Infectious Diseases, Chonnam National University Medical School, Gwangju 61648, Korea.
Jae-Ho JeongDepartment of Microbiology, Chonnam National University Medical School, Gwangju 61468, Korea.
Yoon Seok JungNational Creative Research Initiatives Center for Nuclear Receptor Signals, School of Biological Sciences and Technology, Chonnam National University, Gwangju 61186, Korea.
Shee Eun LeeDepartment of Pharmacology and Dental Therapeutics, School of Dentistry, Chonnam National University, Gwangju 61186, Korea.
Hee-Chang JangDepartment of Infectious Diseases, Chonnam National University Medical School, Gwangju 61648, Korea.
Sook-In JungDepartment of Infectious Diseases, Chonnam National University Medical School, Gwangju 61648, Korea.ORCID 0000-0002-1577-678X
Hueng-Sik ChoiNational Creative Research Initiatives Center for Nuclear Receptor Signals, School of Biological Sciences and Technology, Chonnam National University, Gwangju 61186, Korea.
Joon Haeng RheeDepartment of Molecular Medicine (BK21plus), Chonnam National University Graduate School, Gwangju 61468, Korea.ORCID 0000-0003-4018-3203
Sung-Gwon LeeSchool of Biological Sciences and Technology, Chonnam National University, Gwangju 61186, Korea.
Chungoo ParkSchool of Biological Sciences and Technology, Chonnam National University, Gwangju 61186, Korea.ORCID 0000-0002-9545-6654
Miryoung SongDepartment of Bioscience and Biotechnology, Hankuk University of Foreign Studies, Yongin, Gyeonggido 17035, Korea.
Hyon E ChoyDepartment of Microbiology, Chonnam National University Medical School, Gwangju 61468, Korea.
Chonnam National University · KRChonnam National University Hospital · KRHankuk University of Foreign Studies · KR

Funding

Hankuk University of Foreign Studies Research Fund of 2019National Research Foundation of Korea 20110018305National Research Foundation of Korea 2018R1A5A202418113National Research Foundation of Korea 2019R1F1A1063470National Research Foundation of Korea NRF-2017R1A2A1A17069809National Research Foundation of Korea NRF-2019R1C1C1003999
6 · The paper itself

Abstract

Neutropenic sepsis is a fatal consequence of chemotherapy, and septic complications are the principal cause of mortality. Chemotherapy-induced neutropenia leads to the formation of microscopic ulcers in the gastrointestinal epithelium that function as a portal of entry for intraluminal bacteria, which translocate across the intestinal mucosal barrier and gain access to systemic sites, causing septicemia. A cyclophosphamide-induced mouse model was developed to mimic the pathophysiologic sequence of events that occurs in patients with neutropenic sepsis. The TLR5 agonist bacterial flagellin derived from

Indexed as

chemotherapycytotoxicityEnterobacteriaceaelipocalin 2neutropeniasepsis

Identifiers

PMID32365611
PMCPMC7284693
OpenAlexW3022772535

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.