Evidence map›Paper›PMID 32365482›Full record

ArticleInternational journal of molecular sciences2020

Novel Indole-Based Hydrazones as Potent Inhibitors of the α-class Carbonic Anhydrase from Pathogenic Bacterium

Kübra Demir-Yazıcı, Özlen Güzel-Akdemir, Andrea Angeli, Claudiu T Supuran, Atilla Akdemir

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Bisindole Compounds-Synthesis and Medicinal Properties.Antibiotics (Basel, Switzerland) · 2024
    Review
  2. Benzenesulfonamide derivatives asJournal of enzyme inhibition and medicinal chemistry · 2023
    Article
  3. Carbonic Anhydrases: A Superfamily of Ubiquitous Enzymes.International journal of molecular sciences · 2023
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Kübra Demir-YazıcıDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Istanbul University, Beyazit, 34116 Istanbul, Turkey.ORCID 0000-0001-9928-4733
Özlen Güzel-AkdemirDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Istanbul University, Beyazit, 34116 Istanbul, Turkey.ORCID 0000-0003-3680-1945
Andrea AngeliNeurofarba Department, Section of Pharmaceutical and Nutriceutical Sciences, Università degli Studi di Firenze, Via U. Schiff 6, 50019 Sesto Fiorentino (Florence), Italy.ORCID 0000-0002-1470-7192
Claudiu T SupuranNeurofarba Department, Section of Pharmaceutical and Nutriceutical Sciences, Università degli Studi di Firenze, Via U. Schiff 6, 50019 Sesto Fiorentino (Florence), Italy.ORCID 0000-0003-4262-0323
Atilla AkdemirComputer-aided Drug Discovery Laboratory, Department of Pharmacology, Faculty of Pharmacy, Bezmialem Vakif University, Fatih, 34093 Istanbul, Turkey.ORCID 0000-0001-8416-0471
Istanbul University · TRUniversity of Florence · ITBezmiâlem Vakıf Üniversitesi · TR

Funding

Bilimsel Araştirma Projeleri Birimi, Istanbul Üniversitesi TSA-2019-30535
6 · The paper itself

Abstract

Due to the increasing resistance of currently used antimicrobial drugs, there is an urgent problem for the treatment of cholera disease, selective inhibition of the α-class carbonic anhydrases (CA, EC 4.2.1.1) from the pathogenic bacterium

Indexed as

Amino Acid SequenceBinding SitesCarbonic Anhydrase InhibitorsEnzyme ActivationHydrazonesIndolesMolecular ConformationMolecular Docking SimulationMolecular Dynamics SimulationMolecular StructureProtein BindingStructure-Activity RelationshipVibrio choleraeCarbonic Anhydrase InhibitorsHydrazonesindoleIndolescarbonic anhydraseenzyme inhibitionhydrazonesindolemolecular modelingsulfonamidesVibrio cholerae

Identifiers

PMID32365482
PMCPMC7247680
OpenAlexW3023887199

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.