ArticleAge and ageing2020
Faecal microbiota transplantation as a home therapy to frail older people.
Article in Age and ageing, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05447533 (Frail Old Patients With Clostridioides Difficile Infection), which is not on this map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Frail Old Patients With Clostridioides Difficile Infection: Improvement of Quality in Treatment and Care
Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- The microbiome-gut-brain axis: a new perspective on the pathogenesis and intervention of frailty.Frontiers in cellular and infection microbiology · 2026Review
- The 'obesity paradox' in patients undergoing transcatheter aortic valve implantation. A specialized narrative review.American heart journal plus : cardiology research and practice · 2026Review
- Compassionate Use of Encapsulated MKB-01 Fecal Microbiota Transplantation for RecurrentMicroorganisms · 2025Article
- The Efficacy of Faecal Microbiota Transplant and Rectal Bacteriotherapy in Patients with RecurrentCells · 2022Article
- The Use of Gut Microbial Modulation Strategies as Interventional Strategies for Ageing.Microorganisms · 2022Review
- Emerging Interrelationship Between the Gut Microbiome and Cellular Senescence in the Context of Aging and Disease: Perspectives and Therapeutic Opportunities.Probiotics and antimicrobial proteins · 2022Review
- Long-Term Safety Following Faecal Microbiota Transplantation as a Treatment for RecurrentCells · 2022Review
- Systematic review with meta-analysis: encapsulated faecal microbiota transplantation - evidence for clinical efficacy.Therapeutic advances in gastroenterology · 2021Article
- Fecal Microbiota Transplantation for Refractory Clostridioides Difficile Infection Is Effective and Well Tolerated Even in Very Old Subjects: A Real-Life Study.The journal of nutrition, health & agingArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundClostridioides (Clostridium) difficile infection (CDI) is a leading cause of antibiotics-associated diarrhoea. Faecal microbiota transplantation (FMT) is effective for recurrent CDI and may be provided as a home treatment to frail, older people.
methodsWe present four consecutive patients with recurrent CDI, treated at home using nasojejunal tube-delivered or encapsulated donor faeces. The primary outcome was combined clinical resolution and a negative CD toxin test 8 weeks post-treatment.
resultsAll four patients had severe CDI and all improved clinically following one FMT. Sustained resolution following one FMT was observed in one patient. Two patients had recurrence and received a second FMT using capsules; both achieved resolution. One patient who had recurrence declined from further FMT due to fear of relapse and was established on long-term vancomycin. No adverse events related to FMT were observed.
conclusionFrail older people may benefit from FMT. Home treatment is a viable option and may be considered both for clinical cure and for palliation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.