ArticlePLoS neglected tropical diseases2020
Fine-scale population genetic structure of dengue mosquito vector, Aedes aegypti, in Metropolitan Manila, Philippines.
Article in PLoS neglected tropical diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 44 citations in OpenAlex.
- Insecticide resistance status and high frequency of kdr mutations in Aedes aegypti in Tegucigalpa, Honduras.Parasites & vectors · 2025Article
- Fine-scale adaptive divergence and population genetic structure of Aedes aegypti in Metropolitan Manila, Philippines.Parasites & vectors · 2024Article
- Population genetic structure of Aedes aegypti subspecies in selected geographical locations in Sudan.Scientific reports · 2024Article
- Microsatellite-based analysis revealsEvolutionary applications · 2024Article
- Leveraging insect-specific viruses to elucidate mosquito population structure and dynamics.PLoS pathogens · 2023Review
- Humidity - The overlooked variable in the thermal biology of mosquito-borne disease.Ecology letters · 2023Article
- Genetic Differentiation ofInsects · 2023Article
- Genome-wide detection ofFrontiers in cellular and infection microbiology · 2023Article
- City puzzles: Does urban land scape affect genetic population structure in Aedes aegypti?PLoS neglected tropical diseases · 2022Article
- Genetic Diversity among Four Populations ofPathogens (Basel, Switzerland) · 2022Article
- Novel and Broadly Applicable Microsatellite Markers in Identified Chromosomes of the Philippine Dengue Mosquitoes, Aedes aegypti (Diptera: Culicidae).Journal of medical entomology · 2022Article
- Fine-scale genetic structure andFrontiers in genetics · 2022Article
- Population Genetic Analysis ofFrontiers in genetics · 2022Article
- The influence of roads on the fine-scale population genetic structure of the dengue vector Aedes aegypti (Linnaeus).PLoS neglected tropical diseases · 2021Article
- Surveillance of dengue virus in individual Aedes aegypti mosquitoes collected concurrently with suspected human cases in Tarlac City, Philippines.Parasites & vectors · 2020Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dengue is a highly endemic disease in Southeast Asia and is transmitted primarily by the mosquito, Aedes aegypti. The National Capital Region (NCR) of the Philippines, or Metropolitan Manila, is a highly urbanized area that is greatly affected by this arboviral disease. Urbanization has been shown to increase the dispersal of this mosquito vector. For this reason, we conducted a fine-scale population genetic study of Ae. aegypti in this region. We collected adult Ae. aegypti mosquitoes (n = 526 individuals) within the region (n = 21 study areas) and characterized the present population structure and the genetic relatedness among mosquito populations. We genotyped 11 microsatellite loci from all sampled mosquito individuals and analyzed their genetic diversity, differentiation and structure. The results revealed low genetic differentiation across mosquito populations which suggest high gene flow and/or weak genetic drift among mosquito populations. Bayesian analysis indicated multiple genetic structures (K = 3-6), with no clear genetically distinct population structures. This result implies the passive or long-distance dispersal capability nature Ae. aegypti possibly through human-mediated transportation. The constructed dendrogram in this study describes the potential passive dispersal patterns across Metropolitan Manila. Furthermore, spatial autocorrelation analysis showed the limited and active dispersal capability (<1km) of the mosquito vector. Our findings are consistent with previous studies that investigated the genetic structure and dual (active and passive) dispersal capability of Ae. aegypti in a fine-scale highly urbanized area.
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