Evidence map›Paper›PMID 32364948›Full record

ArticleJournal of the mechanical behavior of biomedical materials2020

Difference in biophysical properties of cancer-initiating cells in melanoma mutated zebrafish.

N Makarova, Vivek Kalaparthi, Andrew Wang, Chris Williams, M E Dokukin, Charles K Kaufman, Leonard Zon, I Sokolov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the mechanical behavior of biomedical materials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

N MakarovaDepartment of Mechanical Engineering, Tufts University, Medford, MA, USA.
Vivek KalaparthiDepartment of Mechanical Engineering, Tufts University, Medford, MA, USA.
Andrew WangDepartment of Mechanical Engineering, Tufts University, Medford, MA, USA.
Chris WilliamsDepartment of Mechanical Engineering, Tufts University, Medford, MA, USA.
M E DokukinDepartment of Mechanical Engineering, Tufts University, Medford, MA, USA; Sarov Physics and Technology Institute, National Research Nuclear University MEPhI, Sarov, Russian Federation.
Charles K KaufmanDepartment of Medicine, Division of Oncology, Washington University, St. Louis, MO, USA.
Leonard ZonBoston Children's Hospital, Boston, MA, USA.
I SokolovDepartment of Mechanical Engineering, Tufts University, Medford, MA, USA; Department of Biomedical Engineering, Tufts University, Medford, MA, USA; Department of Physics, Tufts University, Medford, MA, USA. Electronic address: igor.sokolov@tufts.edu.

Funding

Transcriptional mechanisms and melanomaP01CA163222 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI Kai W Wucherpfennig · 2013 to 2026
$25.3M
Cancer Biology in the ZebrafishR01CA103846 · NCI · CHILDREN'S HOSPITAL BOSTON · PI ZON, LEONARD IRA · 2003 to 2022
$7.5M
NCI NIH HHS P01 CA163222NCI NIH HHS R01 CA103846
6 · The paper itself

Abstract

Despite sharing oncogenetic mutations, only a small number of cells within a given tissue will undergo malignant transformation. Biochemical and physical factors responsible for this cancer-initiation process are not well understood. Here we study biophysical differences of pre-melanoma and melanoma cells in a BRAF

Indexed as

MelanomaZebrafishAnimalsCell Transformation, NeoplasticElasticityElastic ModulusMicroscopy, Atomic ForceAtomic force microscopyCell mechanicsInitiation of cancerPericellular coatZebrafish

Identifiers

PMID32364948
PMCPMC7909363

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.