Evidence map›Paper›PMID 32364847›Full record

ArticleHealth affairs (Project Hope)2020

Impact Of Long-Term Buprenorphine Treatment On Adverse Health Care Outcomes In Medicaid.

Hillary Samples, Arthur Robin Williams, Stephen Crystal, Mark Olfson

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Health affairs (Project Hope), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07148206 (Dronabinol and Epidiolex to Manage Uncontrolled Residual Symptoms of Buprenorphine Initiation Trial), which is not on this map. Cited by 63 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 1 pooled it
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07148206 phase3not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Dronabinol and Epidiolex to Manage Uncontrolled Residual Symptoms of Buprenorphine Initiation Trial

TypeinterventionalSponsorMontefiore Medical CenterRan2026 to 2028Enrolled40ConditionsOpioid Use DisorderArmsDronabinol Capsules, Epidiolex 100 mg/mL Oral Solution, Placebo Dronabinol, Placebo Epidiolex
3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 1 synthesis or guideline pooled it, 90 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Hillary SamplesHillary Samples ( h. samples@columbia. edu ) is a postdoctoral research fellow in the Department of Epidemiology, Columbia University Mailman School of Public Health, in New York City.
Arthur Robin WilliamsArthur Robin Williams is an assistant professor in the Department of Psychiatry, New York State Psychiatric Institute and Columbia University Irving Medical Center, in New York City.
Stephen CrystalStephen Crystal is the Board of Governors Professor in the Institute for Health, Health Care Policy, and Aging Research, Rutgers University, in New Brunswick, New Jersey.
Mark OlfsonMark Olfson is the Elizabeth K. Dollard Professor of Psychiatry, Medicine, and Law in the Department of Psychiatry, Vagelos College of Physicians and Surgeons, and a professor of epidemiology in the Mailman School of Public Health, both at Columbia University; and a research psychiatrist at the New York State Psychiatric Institute, in New York City.
New York Psychoanalytic Society and Institute · USCity University of New York · USRutgers, The State University of New Jersey · US

Funding

Substance Abuse Epidemiology Training Program (SAETP) at Columbia UniversityT32DA031099 · NIDA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DEBORAH S HASIN, Silvia Saboia Martins · 2012 to 2026
$6.1M
Center for Education and Research on Mental Health TherapeuticsU19HS021112 · AHRQ · RUTGERS, THE STATE UNIV OF N.J. · PI CRYSTAL, STEPHEN · 2011 to 2015
$3.9M
SMINET: Applying Evidence to Improve Care and Outcomes in Severe Mental IllnessR18HS023258 · AHRQ · RUTGERS, THE STATE UNIV OF N.J. · PI CRYSTAL, STEPHEN · 2014 to 2017
$3.7M
Opioid Overdoses among Medicaid Beneficiaries: Predictors, Outcomes, and State Policy EffectsR01DA047347 · NIDA · RUTGERS, THE STATE UNIV OF N.J. · PI CRYSTAL, STEPHEN · 2019 to 2022
$3.1M
Improving the treatment cascade of MAT initiation and retention for opioid use disorderK23DA044342 · NIDA · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI WILLIAMS, ARTHUR R · 2017 to 2021
$981k
AHRQ HHS R18 HS023258AHRQ HHS U19 HS021112NIDA NIH HHS K23 DA044342NIDA NIH HHS L30 DA046889NIDA NIH HHS R01 DA047347NIDA NIH HHS T32 DA031099
6 · The paper itself

Abstract

The optimal, or even minimum, duration of medication treatment for opioid use disorder (OUD) needed to improve long-term outcomes has not been established empirically. As a result, health plans set potentially restrictive treatment standards to guide benefits and payment. To address this gap, we used a National Quality Forum measure for OUD medication treatment duration (180 days) to examine the impact of longer treatment on health care outcomes within a key population of Medicaid enrollees. Compared to buprenorphine discontinuation around the National Quality Forum benchmark (six to nine months), longer treatment (at least fifteen months) was associated with relative reductions in the risk of having all-cause inpatient (-52 percent) and emergency department (-26 percent) use, opioid-related hospital use (-128 percent), overdose events (-173 percent), and opioid prescriptions (-120 percent) and in the rate of prescription opioid use (-124 percent). We argue that these clinical benefits provide a rationale for policies that increase access to longer-term buprenorphine treatment, including lengthening the standards for minimum treatment duration.

Indexed as

BuprenorphineOpioid-Related DisordersAnalgesics, OpioidDelivery of Health CareHumansMedicaidOpiate Substitution TreatmentUnited StatesAnalgesics, OpioidBuprenorphineAccess to careAddictionsEmergency departmentsHealth conditionsHealth policyHealth servicesMedicaidOpioid use disorderPharmaceuticalsPrescription drugsquality of care

Identifiers

PMID32364847
PMCPMC7531057
OpenAlexW3021231807

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.