Evidence map›Paper›PMID 32364801›Full record

ArticleThe journal of vascular access2020

Quantitative assessment of required separator fluid volume in multi-infusion settings.

Frank Doesburg, Daniek Middendorp, Willem Dieperink, Wouter Bult, Maarten W Nijsten, Daan J Touw

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of vascular access, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Frank DoesburgDepartment of Critical Care, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID https://orcid.org/0000-0002-9730-0792
Daniek MiddendorpDepartment of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Willem DieperinkDepartment of Critical Care, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID https://orcid.org/0000-0003-2738-7471
Wouter BultDepartment of Critical Care, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Maarten W NijstenDepartment of Critical Care, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Daan J TouwDepartment of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAdministering a separator fluid between incompatible solutions can optimize the use of intravenous lumens. Factors affecting the required separator fluid volume to safely separate incompatible solutions are unknown.

methodsAn intravenous tube (2-m, 2-mL, 6-French) containing methylene blue dye was flushed with separator fluid until a methylene blue concentration ⩽2% from initial was reached. Independent variables were administration rate, dye solvent (glucose 5% and NaCl 0.9%), and separator fluid. In the second part of the study, methylene blue, separator fluid, and eosin yellow were administered in various administration profiles using 2- and 4-mL (2 × 2 m, 4-mL, 6-French) intravenous tubes.

resultsNeither administration rate nor solvent affected the separator fluid volume (

conclusionThe separator fluid volume was neither affected by the administration rate nor by solvent. Glucose 5% required a marginally smaller separator fluid volume than NaCl 0.9%, however its clinical impact is debatable. A larger intravenous tubing volume requires a larger separator fluid volume. However, the ratio of separator fluid volume to the tubing's volume decreases as the tubing volume increases.

Indexed as

Infusion PumpsDrug Delivery SystemsEosine Yellowish-(YS)Equipment DesignGlucoseInfusions, IntravenousMaterials TestingMethylene BlueSodium ChlorideSolventsTime FactorsEosine Yellowish-(YS)GlucoseMethylene BlueSodium ChlorideSolventsdisposable equipmentinfusion pumpsInfusionsintravenousspectrophotometryultravioletvascular access devices

Identifiers

PMID32364801
PMCPMC7675775

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.