ArticleMicrobial biotechnology2020
Exogenous maltose enhances Zebrafish immunity to levofloxacin-resistant Vibrio alginolyticus.
Article in Microbial biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 43 citations in OpenAlex.
- Phosphoenolpyruvate Carboxykinase ControlsBiology · 2026Article
- Maltose aids in the growth ofFEMS microbes · 2026Article
- Exogenous L-Alanine promotes phagocytosis of multidrug-resistant bacterial pathogens.EMBO reports · 2023Article
- Fructose promotes ampicillin killing of antibiotic-resistantVirulence · 2023Article
- The Combination of Antibiotic and Non-Antibiotic Compounds Improves Antibiotic Efficacy against Multidrug-Resistant Bacteria.International journal of molecular sciences · 2023Review
- Comprehensive insights into the metabolism characteristics of small RNA Qrr4 in Vibrio alginolyticus.Applied microbiology and biotechnology · 2023Article
- Aspartate metabolic flux promotes nitric oxide to eliminate both antibiotic-sensitive and -resistantFrontiers in immunology · 2023Article
- Chicken adaptive response to nutrient density: immune function change revealed by transcriptomic analysis of spleen.Frontiers in immunology · 2023Article
- Comparison of freeze-thaw and sonication cycle-based methods for extracting AMR-associated metabolites fromFrontiers in microbiology · 2023Article
- Fructose potentiates the protective efficiency of liveFrontiers in immunology · 2023Article
- Alanine-mediated P cycle boosting enhances the killing efficiency of kasugamycin on antibiotic-resistantFrontiers in microbiology · 2023Article
- Nitrite Promotes ROS Production to Potentiate Cefoperazone-Sulbactam-Mediated Elimination to Lab-Evolved and Clinical-Evolved Pseudomonas aeruginosa.Microbiology spectrum · 2022Article
- Exogenous metabolite feeding on altering antibiotic susceptibility in Gram-negative bacteria through metabolic modulation: a review.Metabolomics : Official journal of the Metabolomic Society · 2022Review
- Article
- Repressed Central Carbon Metabolism and Its Effect on Related Metabolic Pathways in Cefoperazone/Sulbactam-ResistantFrontiers in microbiology · 2022Article
- Untargeted serum metabolomics reveals potential biomarkers and metabolic pathways associated with esophageal cancer.Frontiers in oncology · 2022Article
- Glutamine potentiates gentamicin to kill lab-evolved gentamicin-resistant and clinically isolated multidrug-resistantFrontiers in microbiology · 2022Article
- Synergy of alanine and gentamicin to reduce nitric oxide for elevating killing efficacy to antibiotic-resistantVirulence · 2021Article
- Immunopathogenesis of EmergingJournal of fungi (Basel, Switzerland) · 2021Article
- Serine Metabolism Tunes Immune Responses To PromotemSystems · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding the interplay between bacterial fitness, antibiotic resistance, host immunity and host metabolism could guide treatment and improve immunity against antibiotic-resistant pathogens. The acquisition of levofloxacin (Lev) resistance affects the fitness of Vibrio alginolyticus in vitro and in vivo. Lev-resistant (Lev-R) V. alginolyticus exhibits slow growth, reduced pathogenicity and greater resistance to killing by the host, Danio rerio (zebrafish), than Lev-sensitive (Lev-S) V. alginolyticus, suggesting that Lev-R V. alginolyticus triggers a weaker innate immune response in D. rerio than Lev-S V. alginolyticus. Differences were detected in the metabolome of D. rerio infected with Lev-S or Lev-R V. alginolyticus. Maltose, a crucial metabolite, is significantly downregulated in D. rerio infected with Lev-R V. alginolyticus, and exogenous maltose enhances the immune response of D. rerio to Lev-R V. alginolyticus, leading to better clearance of the infection. Furthermore, we demonstrate that exogenous maltose stimulates the host production of lysozyme and its binding to Lev-R V. alginolyticus, which depends on bacterial membrane potential. We suggest that exogenous exposure to crucial metabolites could be an effective strategy for treating and/or managing infections with antibiotic-resistant bacteria.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.