Evidence map›Paper›PMID 32364668›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2020

Short Total Synthesis of Ajoene, (E,Z)-4,5,9-Trithiadodeca-1,6,11-triene 9-oxide, in Batch and (E,Z)-4,5,9-Trithiadodeca-1,7,11-triene in Continuous Flow.

Marina Yamamoto Raynbird, Filipa Silva, Harry Smallman, Shaista S Khokhar, Daniel Neef, Gareth J S Evans, Thomas Wirth

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Marina Yamamoto RaynbirdSchool of Chemistry, Cardiff University, Park Place, Main Building, Cardiff, CF10 3AT, UK.
Filipa SilvaSchool of Chemistry, Cardiff University, Park Place, Main Building, Cardiff, CF10 3AT, UK.
Harry SmallmanSchool of Chemistry, Cardiff University, Park Place, Main Building, Cardiff, CF10 3AT, UK.
Shaista S KhokharNeem Biotech, Roseheyworth Business Park North, Abertillery, NP13 1SX, UK.
Daniel NeefNeem Biotech, Roseheyworth Business Park North, Abertillery, NP13 1SX, UK.
Gareth J S EvansNeem Biotech, Roseheyworth Business Park North, Abertillery, NP13 1SX, UK.
Thomas WirthSchool of Chemistry, Cardiff University, Park Place, Main Building, Cardiff, CF10 3AT, UK.ORCID http://orcid.org/0000-0002-8990-0667
Cardiff University · GBBiotech Park · IN

Funding

KESS
6 · The paper itself

Abstract

A short total synthesis of ajoene, (E,Z)-4,5,9-trithiadodeca-1,6,11-triene 9-oxide, has been achieved over six steps. In addition, a continuous flow synthesis under mild reaction conditions to (E,Z)-4,5,9-trithiadodeca-1,7,11-triene is described starting from simple and easily accessible starting materials. Over four steps including propargylation, radical addition of thioacetate, deprotection, and disulfide formation/ allylation, the target product can be obtained at a rate of 0.26 g h

Indexed as

ajoenedisulfidesflow chemistrygarlicorganosulfur compounds

Identifiers

PMID32364668
PMCPMC7384054
OpenAlexW3021862989

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.