ArticleeLife2020
Intravascular flow stimulates PKD2 (polycystin-2) channels in endothelial cells to reduce blood pressure.
Erratum issuedOpen access · goldAbstract read
In one paragraph
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 44 papers.
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0cells of the map it votes in
44citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
What it found
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Who cites it
44 citing papers in PubMed, 47 citations in OpenAlex.
- Polycystin-1 suppresses apoptotic signalling in endothelial cells and protects from atherosclerosis.Cardiovascular research · 2026Article
- Endothelial dysfunction: A central mechanism linking autosomal dominant polycystic kidney disease and intracranial aneurysms (Review).International journal of molecular medicine · 2026Review
- The nonexcitable smooth muscle: remodeling the smooth muscle ion transport toolkit in disease.Physiological reviews · 2026Review
- Cardiac mechanotransduction from development to disease.APL bioengineering · 2026Review
- Physiological functions and pharmacological targeting of transient receptor potential channels.Pharmacological reviews · 2025Review
- PIEZO Force Sensing in Vascular Biology: An Explosion of New Knowledge, Concepts and Opportunity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Endothelial CYB5R3 couples store-operated calcium entry to TRPV2 activation and vascular fitness.bioRxiv : the preprint server for biology · 2025Article
- The machinery of healthy vasodilatation: an overview.Pflugers Archiv : European journal of physiology · 2025Review
- Physiologic mechanisms underlying polycystic kidney disease.Physiological reviews · 2025Review
- Metabolic Reprogramming in Autosomal Dominant Polycystic Kidney Disease: Role in Cystogenesis and Novel Therapeutic Approaches.Biomedicines · 2025Review
- Microvascular aberrations found in human polycystic kidneys are an early feature in a Pkd1 mutant mouse model.Disease models & mechanisms · 2025Article
- Transient Receptor Potential Channels in Vascular Mechanotransduction.American journal of hypertension · 2025Review
- Cardiac Localized Polycystin-2 in the Natriuretic Peptide Signaling Pathway and Hypertension.Journal of the American Society of Nephrology : JASN · 2025Article
- The mutual interaction of TRPC5 channel with polycystin proteins.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2025Article
- Review
- Role of transient receptor potential channels in the regulation of vascular tone.Drug discovery today · 2024Review
- Spontaneous Coronary Artery Dissection in Patients with Autosomal Dominant Polycystic Kidney Disease: A Systematic Review of the Literature.Journal of personalized medicine · 2024Review
- Vascular polycystin proteins in health and disease.Microcirculation (New York, N.Y. : 1994) · 2024Review
- Cardiovascular perspectives of the TRP channel polycystin 2.The Journal of physiology · 2024Article
- Mechanosensing by Vascular Endothelium.Annual review of physiology · 2024Review
Corrections and comments
- Erratum issued
Authors and funding
10 authors at 1 institution in 1 country.
Charles E MacKayDepartment of Physiology University of Tennessee Health Science Center Memphis, Memphis, United States.ORCID 0000-0002-2875-0677
M Dennis LeoDepartment of Physiology University of Tennessee Health Science Center Memphis, Memphis, United States.
Carlos Fernández-PeñaDepartment of Physiology University of Tennessee Health Science Center Memphis, Memphis, United States.ORCID 0000-0002-0726-3204
Raquibul HasanDepartment of Physiology University of Tennessee Health Science Center Memphis, Memphis, United States.
Wen YinDepartment of Physiology University of Tennessee Health Science Center Memphis, Memphis, United States.
Alejandro Mata-DaboinDepartment of Physiology University of Tennessee Health Science Center Memphis, Memphis, United States.
Simon BulleyDepartment of Physiology University of Tennessee Health Science Center Memphis, Memphis, United States.ORCID 0000-0001-5985-0489
Jesse GammonsDepartment of Physiology University of Tennessee Health Science Center Memphis, Memphis, United States.
Salvatore MancarellaDepartment of Physiology University of Tennessee Health Science Center Memphis, Memphis, United States.
Jonathan H JaggarDepartment of Physiology University of Tennessee Health Science Center Memphis, Memphis, United States.ORCID 0000-0003-1505-3335
University of Tennessee Health Science Center · US
Funding
Endothelial cell potassium channelsR01HL137745 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI JAGGAR, JONATHAN H · 2017 to 2020
$2.0MChloride channels in diabetic vascular diseaseR01HL149662 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI LEO, M. DENNIS MARCUS · 2020 to 2024
$1.9MBlood pressure regulation by smooth muscle cell ion channelsR01HL133256 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI JAGGAR, JONATHAN H · 2017 to 2020
$1.5MAmerican Heart Association 15SDG22680019American Heart Association 16POST30960010American Heart Association 16SDG27460007American Heart Association 20POST35210200NHLBI NIH HHS R01 HL133256NHLBI NIH HHS R01 HL137745NHLBI NIH HHS R01 HL149662
Abstract
PKD2 (polycystin-2, TRPP1), a TRP polycystin channel, is expressed in endothelial cells (ECs), but its physiological functions in this cell type are unclear. Here, we generated inducible, EC-specific
Indexed as
Arterial PressureMechanotransduction, CellularVasodilationAnimalsCalcium SignalingEndothelial CellsHypertensionIntermediate-Conductance Calcium-Activated Potassium ChannelsMaleMembrane PotentialsMesenteric ArteriesMice, KnockoutNitric OxideNitric Oxide Synthase Type IIIPhosphorylationRegional Blood FlowIntermediate-Conductance Calcium-Activated Potassium ChannelsNitric OxideNitric Oxide Synthase Type IIINos3 protein, mouseSmall-Conductance Calcium-Activated Potassium ChannelsTRPP Cation Channelsblood pressureendothelial cellflow mediated-vasodilationmolecular biophysicsmousepolycystin-2structural biology
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.