Evidence map›Paper›PMID 32364493›Full record

ArticleeLife2020

Parkin contributes to synaptic vesicle autophagy in Bassoon-deficient mice.

Sheila Hoffmann-Conaway, Marisa M Brockmann, Katharina Schneider, Anil Annamneedi, Kazi Atikur Rahman, Christine Bruns, Kathrin Textoris-Taube, Thorsten Trimbuch, Karl-Heinz Smalla, Christian Rosenmund and 3 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 63 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. AnalysisbioRxiv : the preprint server for biology · 2025
    Article
  6. Review
  7. Article
  8. Turning garbage into gold: Autophagy in synaptic function.Current opinion in neurobiology · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Behavioral and histological analyses of the mouseFrontiers in neuroscience · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Sheila Hoffmann-ConawayGerman Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.
Marisa M BrockmannCharité - Universitätsmedizin Berlin, Institute of Neurobiology, Berlin, Germany.ORCID 0000-0002-1386-5359
Katharina SchneiderGerman Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.
Anil AnnamneediLeibniz Institute for Neurobiology, Magdeburg, Germany.
Kazi Atikur RahmanGerman Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.ORCID 0000-0001-8124-6026
Christine BrunsGerman Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.
Kathrin Textoris-TaubeCharité - Universitätsmedizin Berlin, Institute of Biochemistry, Core Facility High Throughput Mass Spectrometry, Berlin, Germany.
Thorsten TrimbuchCharité - Universitätsmedizin Berlin, Institute of Neurobiology, Berlin, Germany.
Karl-Heinz SmallaLeibniz Institute for Neurobiology, Magdeburg, Germany.
Christian RosenmundCharité - Universitätsmedizin Berlin, Institute of Neurobiology, Berlin, Germany.ORCID 0000-0002-3905-2444
Eckart D GundelfingerLeibniz Institute for Neurobiology, Magdeburg, Germany.ORCID 0000-0001-9377-7414
Craig Curtis GarnerGerman Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.ORCID 0000-0003-1970-5417
Carolina Montenegro-VenegasLeibniz Institute for Neurobiology, Magdeburg, Germany.
German Center for Neurodegenerative Diseases · DECenter for Behavioral Brain Sciences · DECharité - Universitätsmedizin Berlin · DE

Funding

BMBF 20150065Federal Government of Germany SFB779/B09Federal Government of Germany SFB958
6 · The paper itself

Abstract

Mechanisms regulating the turnover of synaptic vesicle (SV) proteins are not well understood. They are thought to require poly-ubiquitination and degradation through proteasome, endo-lysosomal or autophagy-related pathways. Bassoon was shown to negatively regulate presynaptic autophagy in part by scaffolding Atg5. Here, we show that increased autophagy in

Indexed as

AutophagyAnimalsCells, CulturedFemaleHippocampusMaleMembrane GlycoproteinsMice, Inbred C57BLMice, KnockoutNerve Tissue ProteinsPresynaptic TerminalsProteolysisProteostasisSignal TransductionSynaptic VesiclesUbiquitinationBsn protein, mouseMembrane GlycoproteinsNerve Tissue Proteinsparkin proteinSv2b protein, mouseUbiquitin-Protein LigasesVesicle-Associated Membrane Protein 2vesicle-associated membrane protein 2, mouseautophagybassoonE3 ubiquitin ligasesmouseneuroscienceparkinpresynapseubiquitination

Identifiers

PMID32364493
PMCPMC7224700
OpenAlexW3022233430

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.