Evidence map›Paper›PMID 32364426›Full record

ArticlePediatric hematology and oncology2020

Spina bifida and pediatric cancers.

Julia E Heck, Pei-Chen Lee, Chia-Kai Wu, Chung-Yi Li, Di He, Noah Federman, Fei Yu, Jorn Olsen, Beate Ritz, Onyebuchi A Arah and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric hematology and oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 3 countries.

Julia E HeckDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles (UCLA), Los Angeles, California, USA.
Pei-Chen LeeDepartment of Health Care Management, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan.
Chia-Kai WuDepartment of Health Care Management, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan.
Chung-Yi LiDepartment of Public Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Di HeDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles (UCLA), Los Angeles, California, USA.
Noah FedermanDepartment of Pediatrics, Geffen School of Medicine, University of California, UCLA, Los Angeles, California, USA.
Fei YuDepartment of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, California, USA.
Jorn OlsenDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles (UCLA), Los Angeles, California, USA.
Beate RitzDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles (UCLA), Los Angeles, California, USA.
Onyebuchi A ArahDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles (UCLA), Los Angeles, California, USA.
Johnni HansenDanish Cancer Society Research Center, Copenhagen, Denmark.
University of California, Los Angeles · USMinistry of Health and Welfare · TWAarhus University · DKDanish Cancer Society · DKNational Taipei University of Nursing and Health Science · TWUCLA Jonsson Comprehensive Cancer Center

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Maternal comorbidities, prescription drug use in pregnancy and childhood cancerR21CA175959 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HECK, JULIA · 2014 to 2015
$323k
Parental Occupation and Childhood CancersR03ES021643 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HECK, JULIA · 2012 to 2013
$152k
NCATS NIH HHS UL1 TR001881NCI NIH HHS R21 CA175959NIEHS NIH HHS R03 ES021643
6 · The paper itself

Abstract

Spina bifida has been reported to co-occur with pediatric cancer, but comprehensive evaluations remained elusive. We investigated this co-occurrence in two large, population-based studies in Taiwan (N = 1900 cancer cases, 2,077,137 controls) and Denmark (N = 5508 cases, 137,700 controls). Analyses in Denmark were restricted to the period before prenatal diagnostics became available (2004) and pregnancy terminations of fetuses with birth defects became more common. Using national patient and cancer registries, we linked spina bifida and cancer diagnoses among cases and non-cases. The risk of spina bifida among all cancer cases was increased and similar in Denmark [odds ratio (OR)=8.4, 95% confidence interval (CI) 5.1-13.8] and Taiwan (OR = 8.5, 95% CI 4.0-17.8), particularly for central nervous system (CNS) tumors (Denmark: OR = 16.3, 95% CI 8.1-33.0; Taiwan: OR = 26.6, 95% CI 8.5, 83.1), including benign CNS tumors (Denmark: OR = 41.5, 95% CI 21.2, 81.4). These findings suggest the need for comprehensive investigation of shared risk factors in the link between spina bifida and pediatric cancer.

Indexed as

AdolescentCentral Nervous System NeoplasmsChildChild, PreschoolDenmarkHumansInfantNeoplasmsOdds RatioPrevalenceRegistriesRisk FactorsSpinal DysraphismTaiwanYoung AdultBirth defectscentral nervous system tumorschildhood cancer epidemiologyfolatespina bifida

Identifiers

PMID32364426
PMCPMC7577564
OpenAlexW3023692537

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.