Evidence map›Paper›PMID 32364331›Full record

ArticleAdvanced healthcare materials2020

Biodegradable β-Cyclodextrin Conjugated Gelatin Methacryloyl Microneedle for Delivery of Water-Insoluble Drug.

Xingwu Zhou, Zhimin Luo, Avijit Baidya, Han-Jun Kim, Canran Wang, Xing Jiang, Moyuan Qu, Jixiang Zhu, Li Ren, Fereshteh Vajhadin and 16 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 147 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 3 institutions in 4 countries.

Xingwu ZhouDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Zhimin LuoDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Avijit BaidyaDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Han-Jun KimDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Canran WangDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Xing JiangDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Moyuan QuDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Jixiang ZhuDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Li RenDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Fereshteh VajhadinDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Peyton TebonDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Niyuan ZhangDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Yumeng XueDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Yudi FengDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Chengbin XueDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Yi ChenDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
KangJu LeeDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Junmin LeeDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Shiming ZhangDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Chun XuDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Nureddin AshammakhiDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Samad AhadianDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Mehmet Remzi DokmeciDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Zhen GuDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Wujin SunDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Ali KhademhosseiniDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.ORCID 0000-0001-6322-8852
California NanoSystems Institute · USNanjing University of Chinese Medicine · CNYazd University · IR

Funding

Targeted chemotherapy delivery and captureR01EB024403 · NIBIB · MAYO CLINIC ARIZONA · PI KHADEMHOSSEINI, ALI, OKLU, RAHMI · 2017 to 2020
$2.2M
Multifunctional dressing for treatment of diabetic woundsR01GM126831 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI DOKMECI, MEHMET REMZI, TAMAYOL, ALI · 2018 to 2021
$1.3M
NIBIB NIH HHS R01 EB024403NIGMS NIH HHS R01 GM126831
6 · The paper itself

Abstract

Transdermal delivery of water-insoluble drugs via hydrogel-based microneedle (MN) arrays is crucial for improving their therapeutic efficacies. However, direct loading of water-insoluble drug into hydrophilic matrices remains challenging. Here, a biodegradable MN array patch that is fabricated from naturally derived polymer conjugates of gelatin methacryloyl and β-cyclodextrin (GelMA-β-CD) is reported. When curcumin, an unstable and water-insoluble anticancer drug, is loaded as a model drug, its stability and solubility are improved due to the formation of an inclusion complex. The polymer-drug complex GelMA-β-CD/CUR can be formulated into MN arrays with sufficient mechanical strength for skin penetration and tunable drug release profile. Anticancer efficacy of released curcumin is observed in three-dimensional B16F10 melanoma models. The GelMA-β-CD/CUR MN exhibits relatively higher therapeutic efficacy through more localized and deeper penetrated manner compared with a control nontransdermal patch. In vivo studies also verify biocompatibility and degradability of the GelMA-β-CD MN arrays patch.

Indexed as

beta-CyclodextrinsGelatinAdministration, CutaneousDrug Delivery SystemsNeedlesWaterbeta-CyclodextrinsGelatinWatergelatin methacryloylmicroneedlestransdermal deliverywater insoluble drugsβ-cyclodextrin

Identifiers

PMID32364331
PMCPMC7462883
OpenAlexW3022475614

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.