ArticleJournal of experimental botany2020
PaACL silencing accelerates flower senescence and changes the proteome to maintain metabolic homeostasis in Petunia hybrida.
Article in Journal of experimental botany, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed.
- Integrated Proteomics and Metabolomics Analysis Reveals Regulatory Mechanisms Underlying Flower Bud Development in Camellia drupifera.Biochemical genetics · 2026Article
- Plant-Microbiome Interactions in Medicinal Plants: A Synergistic Partnership for Biomass Production and Secondary Metabolite Accumulation.Microorganisms · 2026Review
- ADA2 Forms Nuclear Condensates with GCN5 and ATP-Citrate Lyase (ACL) to Modulate H3K9 Acetylation at Genes Functioning in Rice Meristems.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Acetate prevents pistil dysfunction in rice under heat stress by inducing methyl jasmonate and quercetin synthesis.Journal of advanced research · 2025Article
- Transketolase-mediated erythrose-4-phosphate provides an essential source for anthocyanin biosynthesis in petunia.Horticulture research · 2025Article
- Regulation of mNature plants · 2025Article
- Advances in the study of senescence mechanisms in the genusHorticulture research · 2025Article
- Lysine acetylation of histone acetyltransferase adaptor protein ADA2 is a mechanism of metabolic control of chromatin modification in plants.Nature plants · 2024Article
- How far can omics go in unveiling the mechanisms of floral senescence?Biochemical Society transactions · 2023Article
- ACL and HAT1 form a nuclear module to acetylate histone H4K5 and promote cell proliferation.Nature communications · 2023Article
- ROS-stimulated protein lysine acetylation is required for crown root development in rice.Journal of advanced research · 2023Article
- The SmMYB36-SmERF6/SmERF115 module regulates the biosynthesis of tanshinones and phenolic acids inHorticulture research · 2023Article
- Comparative Transcriptome Analysis of Flower Senescence ofCurrent genomics · 2022Article
- Advances in proteome-wide analysis of plant lysine acetylation.Plant communications · 2022Review
Corrections and comments
- Erratum issued
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytosolic acetyl-CoA is an intermediate of the synthesis of most secondary metabolites and the source of acetyl for protein acetylation. The formation of cytosolic acetyl-CoA from citrate is catalysed by ATP-citrate lyase (ACL). However, the function of ACL in global metabolite synthesis and global protein acetylation is not well known. Here, four genes, PaACLA1, PaACLA2, PaACLB1, and PaACLB2, which encode the ACLA and ACLB subunits of ACL in Petunia axillaris, were identified as the same sequences in Petunia hybrida 'Ultra'. Silencing of PaACLA1-A2 and PaACLB1-B2 led to abnormal leaf and flower development, reduced total anthocyanin content, and accelerated flower senescence in petunia 'Ultra'. Metabolome and acetylome analysis revealed that PaACLB1-B2 silencing increased the content of many downstream metabolites of acetyl-CoA metabolism and the levels of acetylation of many proteins in petunia corollas. Mechanistically, the metabolic stress induced by reduction of acetyl-CoA in PaACL-silenced petunia corollas caused global and specific changes in the transcriptome, the proteome, and the acetylome, with the effect of maintaining metabolic homeostasis. In addition, the global proteome and acetylome were negatively correlated under acetyl-CoA deficiency. Together, our results suggest that ACL acts as an important metabolic regulator that maintains metabolic homeostasis by promoting changes in the transcriptome, proteome. and acetylome.
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