ArticleTechnology and health care : official journal of the European Society for Engineering and Medicine2020
Effect of potassium channel noise on nerve discharge based on the Chay model.
Article in Technology and health care : official journal of the European Society for Engineering and Medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed, 3 citations in OpenAlex.
- Automatic classification of nerve discharge rhythms based on sparse auto-encoder and time series feature.BMC bioinformatics · 2022Article
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4 authors at 2 institutions in 1 country.
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Abstract
backgroundThe nervous system senses and transmits information through the firing behavior of neurons, and this process is affected by various noises. However, in the previous study of the influence of noise on nerve discharge, the channel of some noise effects is not clear, and the difference from other noises was not examined.
objectiveTo construct ion channel noise which is more biologically significant, and to clarify the basic characteristics of the random firing rhythm of neurons generated by different types of noise acting on ion channels.
methodBased on the dynamics of the ion channel, we constructed ion channel noise. We simulated the nerve discharge based on the Chay model of potassium ion channel noise, and used the nonlinear time series analysis method to measure the certainty and randomness of nerve discharge.
resultsIn the Chay model with potassium ion noise, the chaotic rhythm defined by the original model could be effectively unified with the random rhythm simulated by the previous random Chay model into a periodic bifurcation process.
conclusionThis method clarified the influence of ion channel noise on nerve discharge, better understood the randomness of nerve discharge and provided a more reasonable explanation for the mechanism of nerve discharge.
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