Evidence map›Paper›PMID 32363922›Full record

ArticleExperimental biology and medicine (Maywood, N.J.)2020

Mutations in MC4R facilitate the angiogenic activity in patients with orbital venous malformation.

Xiao-Ming Huang, Wan-Chen Yang, Yang Liu, Dong-Run Tang, Tong Wu, Feng-Yuan Sun

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental biology and medicine (Maywood, N.J.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
  3. Biological identity of orbital cavernous venous malformations.Arquivos brasileiros de oftalmologia · 2024
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Xiao-Ming HuangTianjin Key Laboratory of Retinal Functions and Diseases, Tianjin 300384, China.
Wan-Chen YangTianjin Key Laboratory of Retinal Functions and Diseases, Tianjin 300384, China.
Yang LiuOrbital Disease Institute, Tianjin Medical University Eye Hospital, Tianjin 300384, China.
Dong-Run TangTianjin Key Laboratory of Retinal Functions and Diseases, Tianjin 300384, China.
Tong WuTianjin Key Laboratory of Retinal Functions and Diseases, Tianjin 300384, China.
Feng-Yuan SunTianjin Key Laboratory of Retinal Functions and Diseases, Tianjin 300384, China.ORCID 0000-0002-6554-491X
Tianjin Medical University Eye Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

impact statementThe detailed molecular mechanism of orbital venous malformation (OVM) is still not clear. Using whole exome sequencing, 4 types of melanocortin 4 receptor (MC4R) mutation were detected in 7 of 27 patients with OVM, and all types of MC4R mutations resulted in the upregulation of MC4R expression.

Indexed as

AdultCell CycleCell ProliferationEndothelial CellsFemaleGenetic Predisposition to DiseaseHumansMaleMiddle AgedMutationNeovascularization, PhysiologicOrbitReceptor, Melanocortin, Type 4Vascular MalformationsVeinsMC4R protein, humanReceptor, Melanocortin, Type 4endothelial cellsmelanocortin 4 receptorOrbital venous malformation

Identifiers

PMID32363922
PMCPMC7427181
OpenAlexW3022740752

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.