ArticleInternational journal of geriatric psychiatry2020
Neuropsychiatric symptom profiles of community-dwelling persons living with dementia: Factor structures revisited.
Article in International journal of geriatric psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- The Association Between Caregiver Psychosocial Factors and Depressive Symptoms in People With Dementia: A Systematic Review and Meta-Analysis.Journal of advanced nursing · 2026Pooled it
- Associations between caregiver mastery and anxiety in persons living with dementia: A study of dyads living in community.Geriatric nursing (New York, N.Y.)Trial
- Neuropsychiatric symptoms in preclinical and clinically manifest dementia: clusters and their health determinants.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Neuropsychiatric symptoms of dementia and caregiver burden: a systematic review and meta-regression.Dementia & neuropsychologia · 2026Article
- Article
- Clusterization of Behavioral and Psychological Symptoms of Dementia as Assessed by Neuropsychiatric Inventory: A Case Against the Use of Principal Component Analysis.Journal of Alzheimer's disease : JAD · 2024Article
- Timed Activity to Minimize Sleep Disturbance in People With Cognitive Impairment.Innovation in aging · 2024Article
- Better caregiver mastery is associated with less anxiety in individuals with cognitive impairment.BMC nursing · 2023Article
- Burden in caregivers of primary care patients with dementia: influence of neuropsychiatric symptoms according to disease stage (NeDEM project).BMC geriatrics · 2023Observational
- Specific agitation behaviours in dementia differentially contribute to aspects of caregiver burden.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2022Article
- Elderspeak communication and pain severity as modifiable factors to rejection of care in hospital dementia care.Journal of the American Geriatrics Society · 2022Article
- Neuropsychiatric symptoms and subsyndromes in patients with different stages of dementia in primary care follow-up (NeDEM project): a cross-sectional study.BMC geriatrics · 2022Article
- WeCareAdvisor, an Online Platform to Help Family Caregivers Manage Dementia-Related Behavioral Symptoms: an Efficacy Trial in the Time of COVID-19.Journal of technology in behavioral science · 2022Article
- What evidence is there for implicating the brain orexin system in neuropsychiatric symptoms in dementia?Frontiers in psychiatry · 2022Article
- Using Geographic Information Systems (GIS) for Targeted National Recruitment of Community-Dwelling Caregivers Managing Dementia-Related Behavioral and Psychological Symptoms: A Recruitment Approach for a Randomized Clinical Trial.Journal of geographic information system · 2021Article
- Interrelationship of Sleep Disturbances and Cognitive Status on Mortality.American journal of Alzheimer's disease and other dementiasArticle
- A qualitative study of music-based intervention use for Alzheimer's disease in elder care communities.Journal of Alzheimer's disease reportsArticle
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesMost persons living with dementia (PLWD) will develop neuropsychiatric symptoms (NPS) at some point. NPS are often clustered into subsyndromes with other related symptoms, but the evidence supporting commonly used clusters is insufficient. We reexamine behavioral clusters in community-dwelling PLWD and identify associated risk factors and potential contributors.
methodsThis study used baseline data from a longitudinal behavioral intervention study of 250 community-dwelling older adults with dementia and their caregivers. Using exploratory factor analysis (principal component analysis [PCA]), the factor structure of NPS frequency scores of the Neuropsychiatric Inventory (NPI-C) was evaluated. Multiple linear regressions assessed the association of the derived behavioral clusters with caregiver burden, caregiver depression, and quality of life of the PLWD.
resultsPCA yielded eight behavioral clusters (factors): 1 = Aggression/Rejection of Care, 2 = Apathy/Withdrawal, 3 = Restlessness/Agitation, 4 = Anxiety, 5 = Impulsivity/Disinhibition, 6 = Psychosis, 7 = Circadian Disturbance, and 8 = Depression. In multiple linear regressions, caregiver burden was significantly influenced by the anxiety cluster, caregiver depression was significantly influenced by the apathy/withdrawal cluster, and quality of life of the PLWD was significantly associated with the anxiety and circadian disturbance clusters.
conclusionsOur eight derived behavioral clusters suggest that commonly accepted clusters of NPS may not reflect the clinical reality for community-dwelling PLWD. Behavioral clusters appear to differentially impact and put caregivers and PLWD at risk such that personalized intervention strategies are warranted. J Am Geriatr Soc 68:-, 2020.
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