Evidence map›Paper›PMID 32363570›Full record

ArticleMolecular genetics and genomics : MGG2020

Multifaceted genome-wide study identifies novel regulatory loci in SLC22A11 and ZNF45 for body mass index in Indians.

Anil K Giri, Gauri Prasad, Khushdeep Bandesh, Vaisak Parekatt, Anubha Mahajan, Priyanka Banerjee, Yasmeen Kauser, Shraddha Chakraborty, Donaka Rajashekar, INDICO and 6 more

Abstract read
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In one paragraph

Article in Molecular genetics and genomics : MGG, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Recent progress in epigenetics of obesity.Diabetology & metabolic syndrome · 2022
    Review
  4. Article
  5. Article
  6. Genetics of early growth traits.Human molecular genetics · 2020
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Anil K GiriGenomics and Molecular Medicine Unit, CSIR-Institute of Genomics and Integrative Biology, New Delhi, India.
Gauri PrasadGenomics and Molecular Medicine Unit, CSIR-Institute of Genomics and Integrative Biology, New Delhi, India.
Khushdeep BandeshGenomics and Molecular Medicine Unit, CSIR-Institute of Genomics and Integrative Biology, New Delhi, India.
Vaisak ParekattGenomics and Molecular Medicine Unit, CSIR-Institute of Genomics and Integrative Biology, New Delhi, India.
Anubha MahajanWellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Priyanka BanerjeeGenomics and Molecular Medicine Unit, CSIR-Institute of Genomics and Integrative Biology, New Delhi, India.
Yasmeen KauserGenomics and Molecular Medicine Unit, CSIR-Institute of Genomics and Integrative Biology, New Delhi, India.
Shraddha ChakrabortyGenomics and Molecular Medicine Unit, CSIR-Institute of Genomics and Integrative Biology, New Delhi, India.
Donaka RajashekarGenomics and Molecular Medicine Unit, CSIR-Institute of Genomics and Integrative Biology, New Delhi, India.
INDICO
Abhay SharmaGenomics and Molecular Medicine Unit, CSIR-Institute of Genomics and Integrative Biology, New Delhi, India.
Sandeep Kumar MathurDepartment of Endocrinology, Sawai Man Singh Medical College, Jaipur, Rajasthan, India.
Analabha BasuNational Institute of Biomedical Genomics, Kalyani, West Bengal, India.
Mark I McCarthyWellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Nikhil TandonDepartment of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India. nikhil_tandon@hotmail.com.
Dwaipayan BharadwajAcademy of Scientific and Innovative Research, CSIR-Institute of Genomics and Integrative Biology Campus, New Delhi, India. db@jnu.ac.in.ORCID http://orcid.org/0000-0001-5268-8482
Institute of Genomics and Integrative Biology · INCentre for Human Genetics · GBSMS Medical College · INJawaharlal Nehru University · IN

Funding

Council of Scientific and Industrial Research Centre for CardiovascularCouncil of Scientific and Industrial Research Metabolic Disease Research [CARDIOMED] project [Grant No: BSC0122-(12)]Department of Biotechnology (DBT) BIOCHILDDepartment of Science & Technology PURSE II CDST/SR/PURSE PHASE II/11
6 · The paper itself

Abstract

Obesity, a risk factor for multiple diseases (e.g. diabetes, hypertension, cancers) originates through complex interactions between genes and prevailing environment (food habit and lifestyle) that varies across populations. Indians exhibit a unique obesity phenotype with high abdominal adiposity for a given body weight compared to matched white populations suggesting presence of population-specific genetic and environmental factors influencing obesity. However, Indian population-specific genetic contributors for obesity have not been explored yet. Therefore, to identify potential genetic contributors, we performed a two-staged genome-wide association study (GWAS) for body mass index (BMI), a common measure to evaluate obesity in 5973 Indian adults and the lead findings were further replicated in 1286 Indian adolescents. Our study revealed novel association of variants-rs6913677 in BAI3 gene (p = 1.08 × 10

Indexed as

Genome-Wide Association StudyAdolescentAdultAsian PeopleBody Mass IndexDNA MethylationFemaleGene-Environment InteractionGenetic Predisposition to DiseaseHumansIndians, North AmericanKruppel-Like Transcription FactorsMaleObesityOrganic Anion Transporters, Sodium-IndependentPolymorphism, Single NucleotideKruppel-Like Transcription FactorsOrganic Anion Transporters, Sodium-IndependentRepressor ProteinsSLC22A11 protein, humanZNF45 protein, humanBAI3Body mass indexDNA methylationGene regulationGWASSLC22A11ZNF45

Identifiers

PMID32363570
OpenAlexW3020970183

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.