Evidence map›Paper›PMID 32363432›Full record

ArticleJournal of neurology2020

Characteristic muscle signatures assessed by quantitative MRI in patients with Bethlem myopathy.

Ruth Salim, Julia Rebecka Dahlqvist, Tahmina Khawajazada, Konni Kass, Karoline Lolk Revsbech, Josefine de Stricker Borch, Aisha Munawar Sheikh, John Vissing

Abstract read
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In one paragraph

Article in Journal of neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Ruth SalimCopenhagen Neuromuscular Center, Section 3342, Department of Neurology, University of Copenhagen, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark. Ruth.Salim.01@regionh.dk.ORCID http://orcid.org/0000-0002-6828-114X
Julia Rebecka DahlqvistCopenhagen Neuromuscular Center, Section 3342, Department of Neurology, University of Copenhagen, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark.
Tahmina KhawajazadaCopenhagen Neuromuscular Center, Section 3342, Department of Neurology, University of Copenhagen, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark.
Konni KassCopenhagen Neuromuscular Center, Section 3342, Department of Neurology, University of Copenhagen, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark.
Karoline Lolk RevsbechCopenhagen Neuromuscular Center, Section 3342, Department of Neurology, University of Copenhagen, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark.
Josefine de Stricker BorchCopenhagen Neuromuscular Center, Section 3342, Department of Neurology, University of Copenhagen, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark.
Aisha Munawar SheikhCopenhagen Neuromuscular Center, Section 3342, Department of Neurology, University of Copenhagen, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark.
John VissingCopenhagen Neuromuscular Center, Section 3342, Department of Neurology, University of Copenhagen, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark.
University of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Using MRI, the main aim was to (1) map the pattern of muscle involvement by assessing fat fraction and (2) investigate frequency of target and sandwich signs in 42 muscles of patients with Bethlem myopathy (BM). Fifteen BM patients were included. Results were compared to findings in 8 healthy controls and 50 patients with four other types of muscular dystrophies. All muscles, except one, showed higher fat fraction in BM patients vs healthy controls (p < 0.05) with an overall proximal muscle affection, resembling a limb girdle-like pattern. In moderate patients, the specificity was 90% for the sandwich sign and 98% for the target sign. Sensitivity for both signs was 100%. Twelve BM patients had sandwich sign in other muscles than the vastus lateralis. Muscle strength correlated with fat fraction. Mean fat fraction in the psoas major was 39% in BM patients, which was considerably higher than in 3 of the 4 muscular dystrophy control diseases. The presence of signs in conjunction with severe affection of the psoas major muscle can serve as a diagnostic tool in BM. The high level of STIR lesions in muscles of BM patients warrants further investigations.

Indexed as

ContractureMuscular DystrophiesHumansMagnetic Resonance ImagingMuscle, SkeletalBethlem myopathyQuantitative MRISandwich signTarget signThe psoas major muscle

Identifiers

PMID32363432
OpenAlexW3022436907

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.