Evidence map›Paper›PMID 32363318›Full record

ArticleHepatology communications2020

Differential Associations of Circulating MicroRNAs With Pathogenic Factors in NAFLD.

Ghideon Ezaz, Hirsh D Trivedi, Margery A Connelly, Claudia Filozof, Kellie Howard, Mark L Parrish, Misung Kim, Mark A Herman, Imad Nasser, Nezam H Afdhal and 2 more

Open access · goldAbstract read
In one paragraph

Article in Hepatology communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 3 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Ghideon EzazDivision of Hepatology Icahn School of Medicine at Mount Sinai New York NY.ORCID https://orcid.org/0000-0001-6492-9706
Hirsh D TrivediDivision of Gastroenterology & Hepatology Beth Israel Deaconess Medical Center Harvard Medical School Boston MA.ORCID https://orcid.org/0000-0002-8328-9211
Margery A ConnellyLaboratory Corporation of America® Holdings (LabCorp) Morrisville NC.
Claudia FilozofCovance Clinical Services Madrid Spain.
Kellie HowardCovance Genomics Laboratory Redmond WA.
Mark L ParrishCovance Genomics Laboratory Redmond WA.
Misung KimDivision of Endocrinology Beth Israel Deaconess Medical Center Harvard Medical School Boston MA.
Mark A HermanDivision of Endocrinology Duke University Medical Center Durham NC.
Imad NasserDepartment of Pathology Beth Israel Deaconess Medical Center Harvard Medical School Boston MA.
Nezam H AfdhalDivision of Gastroenterology & Hepatology Beth Israel Deaconess Medical Center Harvard Medical School Boston MA.
Z Gordon JiangDivision of Gastroenterology & Hepatology Beth Israel Deaconess Medical Center Harvard Medical School Boston MA.ORCID https://orcid.org/0000-0003-0495-9940
Michelle LaiDivision of Gastroenterology & Hepatology Beth Israel Deaconess Medical Center Harvard Medical School Boston MA.
Beth Israel Deaconess Medical Center · USCovance (United States) · USDuke Medical Center · USIcahn School of Medicine at Mount Sinai · USLabCorp (United States) · US

Funding

RESEARCH TRAINING IN GASTROENTEROLOGYT32DK007760 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KELLY, CIARAN P · 1999 to 2019
$4.6M
The Role of ChREBP in Fructose Induced Metabolic DiseaseR01DK100425 · NIDDK · DUKE UNIVERSITY · PI HERMAN, MARK A · 2014 to 2023
$3.6M
Adenosine deaminase 2 regulates macrophage phenotype and liver fibrosis in nonalcoholic fatty liver diseaseK08DK115883 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI JIANG, ZHENGHUI GORDON · 2018 to 2022
$839k
NIDDK NIH HHS K08 DK115883NIDDK NIH HHS R01 DK100425NIDDK NIH HHS T32 DK007760
6 · The paper itself

Abstract

Nonalcoholic fatty liver disease (NAFLD) is a heterogeneous disease driven by genetic and environmental factors. MicroRNAs (miRNAs) serve as pleiotropic post-transcriptional regulators of cellular pathways. Although several miRNAs have been associated with NAFLD and fibrosis, there are limited studies in humans examining their differential association with pathogenic factors or histological features of NAFLD. We examined the differential relationships of five of the best-described circulating microRNAs (miR-34a, miR-122, miR-191, miR-192, and miR-200a) with histological features and pathogenic factors of NAFLD. A cross-sectional study was conducted to examine the relationship between relative levels of circulating microRNAs standardized by

Identifiers

PMID32363318
PMCPMC7193128
OpenAlexW3012081488

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.