Evidence map›Paper›PMID 32363207›Full record

ArticleERJ open research2020

Survival benefit of lung transplantation compared with medical management and pulmonary rehabilitation for patients with end-stage COPD.

Irina Timofte, Marniker Wijesinha, Roumen Vesselinov, June Kim, Robert Reed, Pablo G Sanchez, Nicholas Ladikos, Si Pham, Zachary Kon, Keshava Rajagopal and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ERJ open research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Lung transplantation for COPD/pulmonary emphysema.European respiratory review : an official journal of the European Respiratory Society · 2023
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 1 country.

Irina TimofteDept of Medicine, University of Maryland Medical Center, Baltimore, MD, USA.
Marniker WijesinhaDept of Epidemiology and Public Health, University of Maryland Medical Center, Baltimore, MD, USA.
Roumen VesselinovDept of Epidemiology and Public Health, University of Maryland Medical Center, Baltimore, MD, USA.
June KimDept of Medicine, University of Maryland Medical Center, Baltimore, MD, USA.
Robert ReedDept of Medicine, University of Maryland Medical Center, Baltimore, MD, USA.
Pablo G SanchezDept of Cardio Thoracic Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Nicholas LadikosDept of Pharmacy, Suburban Hospital/Johns Hopkins Medicine, Bethesda, MD, USA.
Si PhamDept of Cardio Thoracic Surgery, Mayo Clinic Florida, Jacksonville, FL, USA.
Zachary KonDept of Thoracic Surgery, New York University, New York, NY, USA.
Keshava RajagopalDept of Cardio Thoracic Surgery, University of Texas Health Science Center at Houston, Houston, TX, USA.
Steven M ScharfDept of Medicine, University of Maryland Medical Center, Baltimore, MD, USA.
Robert WiseDept of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID https://orcid.org/0000-0002-8353-2349
Alice L SternbergDept of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
David KaczorowskiDept of Cardio Thoracic Surgery, University of Maryland Medical Center, Baltimore, MD, USA.
Bartley GriffithDept of Cardio Thoracic Surgery, University of Maryland Medical Center, Baltimore, MD, USA.
Michael TerrinDept of Epidemiology and Public Health, University of Maryland Medical Center, Baltimore, MD, USA.
Aldo IaconoR. Adams Cowley Shock Trauma Center, University of Maryland Medical Center, Baltimore, MD, USA.
University of Maryland, Baltimore · USJohns Hopkins University · USJacksonville College · USNew York University · USThe University of Texas Health Science Center at Houston · USUniversity of Pittsburgh · US

Funding

RESEARCH TRAINING IN THE EPIDEMIOLOGY OF AGINGT32AG000262 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI ANN L GRUBER-BALDINI, DENISE L ORWIG · 1998 to 2026
$8.2M
CLINICAL COORDINATING CENTER FOR LVRS-N01HR76119-268076119-268076119N01HR076119 · HR · JOHNS HOPKINS UNIVERSITY · PI PIANTADOSI, STEVEN · 1997 to 2006
$871k
LUNG VOLUME REDUCTION SURGERY--CLINICAL CENTERN01HR076118 · HR · UNIVERSITY OF WASHINGTON · PI ALBERT, RICHARD K · 1997 to 2000
$225k
LUNG VOLUME REDUCTION SURGERY--CLINICAL CENTERN01HR076113 · HR · UNIVERSITY OF PENNSYLVANIA · PI KAISER, LARRY · 1997 to 2000
$208k
CLNICAL CENTER FOR LVRSN01HR076104 · HR · CEDARS-SINAI MEDICAL CENTER · PI MCKENNA, RICHARD · 1997 to 2000
$153k
CLNICAL CENTER FOR THE LVRSN01HR076102 · HR · BRIGHAM AND WOMEN'S HOSPITAL · PI REILLY, JOHN J · 1997 to 2000
$150k
CLINICAL CENTER FOR LVRSN01HR076114 · HR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KEENAN, ROBERT J · 1997 to 2000
$147k
LUNG VOLUME REDUCTION SURGERY--CLINICAL CENTERN01HR076110 · HR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FERNANDO, MARTINEZ J · 1997 to 2000
$146k
LUNG VOLUME REDUCTION SURGERY--CLINICAL CENTERN01HR076111 · HR · NATIONAL JEWISH HEALTH · PI CHERNIACK, REUBEN M · 1997 to 2000
$144k
CLINICAL CENTER FOR THE LUNG VOLUME REDUCTION SURGERYN01HR076106 · HR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBURG, MARK E · 1997 to 2000
$143k
CLINICAL CENTER FOR THE LUNG VOLUME REDUCTION SURGERYN01HR076103 · HR · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI RIES, ANDREW L · 1997 to 2000
$142k
CLNICAL CENTER FOR LVRSN01HR076105 · HR · CLEVELAND CLINIC FOUNDATION · PI MAURER, JANET R. · 1997 to 2000
$137k
NHLBI NIH HHS N01 HR076101NHLBI NIH HHS N01 HR076102NHLBI NIH HHS N01 HR076103NHLBI NIH HHS N01 HR076104NHLBI NIH HHS N01 HR076105NHLBI NIH HHS N01 HR076106NHLBI NIH HHS N01 HR076107NHLBI NIH HHS N01 HR076108NHLBI NIH HHS N01 HR076109NHLBI NIH HHS N01 HR076110NHLBI NIH HHS N01 HR076111NHLBI NIH HHS N01 HR076112NHLBI NIH HHS N01 HR076113NHLBI NIH HHS N01 HR076114NHLBI NIH HHS N01 HR076115NHLBI NIH HHS N01 HR076116NHLBI NIH HHS N01 HR076118NHLBI NIH HHS N01 HR076119NIA NIH HHS T32 AG000262
6 · The paper itself

Abstract

backgroundCOPD patients account for a large proportion of lung transplants; lung transplantation survival benefit for COPD patients is not well established.

methodsWe identified 4521 COPD patients in the United Network for Organ Sharing (UNOS) dataset transplanted from May 2005 to August 2016, and 604 patients assigned to receive pulmonary rehabilitation and medical management in the National Emphysema Treatment Trial (NETT). After trimming the populations for NETT eligibility criteria and data completeness, 1337 UNOS and 596 NETT patients remained. Kaplan-Meier estimates of transplant-free survival from transplantation for UNOS, and NETT randomisation, were compared between propensity score-matched UNOS (n=401) and NETT (n=262) patients.

resultsIn propensity-matched analyses, transplanted patients had better survival compared to medically managed patients in NETT (p=0.003). Stratifying on 6 min walk distance (6 MWD) and FEV

conclusionsOverall survival is better for matched lung transplant patients compared with medical management alone. Patients who derive maximum benefit are those with 6 MWD <1000 ft (∼300 m) or FEV

Identifiers

PMID32363207
PMCPMC7184114
OpenAlexW3020493890

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.