Evidence map›Paper›PMID 32363189›Full record

ArticleFrontiers in cell and developmental biology2020

CD38 Causes Autophagic Flux Inhibition and Cardiac Dysfunction Through a Transcriptional Inhibition Pathway Under Hypoxia/Ischemia Conditions.

Xingyue Zhang, Lingfei Li, Qiong Zhang, Qinglin Wei, Jiezhi Lin, Jiezhi Jia, Junhui Zhang, Tiantian Yan, Yanling Lv, Xupin Jiang and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. CD38 connects the heart and brain.Translational psychiatry · 2025
    Review
  3. NAD metabolism and heart failure: Mechanisms and therapeutic potentials.Journal of molecular and cellular cardiology · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Xingyue ZhangInstitute of Burn Research, Southwest Hospital, Army Medical University, Third Military Medical University, Chongqing, China.
Lingfei LiInstitute of Burn Research, Southwest Hospital, Army Medical University, Third Military Medical University, Chongqing, China.
Qiong ZhangInstitute of Burn Research, Southwest Hospital, Army Medical University, Third Military Medical University, Chongqing, China.
Qinglin WeiCholestatic Liver Diseases Center of the Institute of Digestive Disease, First Affiliated of Army Medical University, Chongqing, China.
Jiezhi LinInstitute of Burn Research, Southwest Hospital, Army Medical University, Third Military Medical University, Chongqing, China.
Jiezhi JiaInstitute of Burn Research, Southwest Hospital, Army Medical University, Third Military Medical University, Chongqing, China.
Junhui ZhangInstitute of Burn Research, Southwest Hospital, Army Medical University, Third Military Medical University, Chongqing, China.
Tiantian YanMilitary Burn Center, The 990th (159th) Hospital of the People's Liberation Army, Zhumadian, China.
Yanling LvInstitute of Burn Research, Southwest Hospital, Army Medical University, Third Military Medical University, Chongqing, China.
Xupin JiangInstitute of Burn Research, Southwest Hospital, Army Medical University, Third Military Medical University, Chongqing, China.
Peng ZhangInstitute of Burn Research, Southwest Hospital, Army Medical University, Third Military Medical University, Chongqing, China.
Huapei SongInstitute of Burn Research, Southwest Hospital, Army Medical University, Third Military Medical University, Chongqing, China.
Dongxia ZhangInstitute of Burn Research, Southwest Hospital, Army Medical University, Third Military Medical University, Chongqing, China.
Yuesheng HuangInstitute of Burn Research, Southwest Hospital, Army Medical University, Third Military Medical University, Chongqing, China.
Southwest Hospital · CNArmy Medical University · CN117th Hospital of People's Liberation Army · CNSouthern University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Induced autophagy is protective against myocardial hypoxia/ischemia (H/I) injury, but evidence regarding the extent of autophagic clearance under H/I and the molecular mechanisms that influence autophagic flux has scarcely been presented. Here, we report that CD38 knockout improved cardiac function and autophagic flux in

Indexed as

autophagosome–lysosome fusionheart diseasenicotinamide adenine dinucleotidepleckstrin homology domain-containing protein family member 1Rab7

Identifiers

PMID32363189
PMCPMC7180518
OpenAlexW3016629947

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.