Evidence map›Paper›PMID 32363114›Full record

ArticleOncoimmunology2020

Targeting ubiquitin protein ligase E3 component N-recognin 5 in cancer cells induces a CD8+ T cell mediated immune response.

Mei Song, Chao Wang, Huan Wang, Tuo Zhang, Jiuqi Li, Robert Benezra, Lotfi Chouchane, Yin-Hao Sun, Xin-Gang Cui, Xiaojing Ma

Open access · goldAbstract read
In one paragraph

Article in Oncoimmunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
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  12. Combining UBR5 and CD163Cancer immunology, immunotherapy : CII · 2021
    Article
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  15. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Mei SongDepartment of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA.
Chao WangDepartment of Urinary Surgery, Gongli Hospital, Second Military Medical University (Naval Medical University), Shanghai, China.
Huan WangSheng Yushou Center of Cell Biology and Immunology, School of Life Sciences and Biotechnology, Shanghai Jiaotong University, Shanghai, China.
Tuo ZhangDepartment of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0001-5396-918X
Jiuqi LiCollege of Biological Sciences, China Agricultural University, Beijing, China.
Robert BenezraCancer Biology and Genetics Program, Sloan-Kettering Institute for Cancer Research, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Lotfi ChouchaneLaboratory of Genetic Medicine and Immunology, Weill Cornell Medicine-Qatar, Qatar Foundation, Doha, Qatar.
Yin-Hao SunDepartment of Urology, Changhai Hospital, Second Military Medical University (Naval Medical University), Shanghai, China.
Xin-Gang CuiDepartment of Urinary Surgery, Gongli Hospital, Second Military Medical University (Naval Medical University), Shanghai, China.
Xiaojing MaDepartment of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA.
Second Military Medical University · CNCornell University · USShanghai Jiao Tong University · CNChina Agricultural University · CNMemorial Sloan Kettering Cancer Center · USWeill Cornell Medical College in Qatar · QA

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
The Role of Id Proteins in Breast TumorigenesisP01CA094060 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI GIANCOTTI, FILIPPO G · 2002 to 2018
$39.4M
Investigation of EDD's extraordinary tumorigenic activitiesR03CA230573 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI MA, XIAOJING · 2018 to 2019
$170k
NCI NIH HHS P01 CA094060NCI NIH HHS P30 CA008748NCI NIH HHS R03 CA230573
6 · The paper itself

Abstract

UBR5 is a nuclear phosphoprotein of obscure functions. Clinical analyses reveal that

Indexed as

Breast NeoplasmsUbiquitin-Protein LigasesCD8-Positive T-LymphocytesFemaleHumansImmunityNeoplasm ProteinsNeoplasm ProteinsrecogninsUbiquitin-Protein LigasesUBR5 protein, humanbreast cancerE3 ligaseimmunotherapymetastasisUBR5

Identifiers

PMID32363114
PMCPMC7185213
OpenAlexW3017113847

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.