Evidence map›Paper›PMID 32362981›Full record

ArticleJournal of hematology2020

Spontaneous Remission in a Patient With Acute Myeloid Leukemia Leading to Undetectable Minimal Residual Disease.

Daniel Helbig, Andres E Quesada, Wenbin Xiao, Mikhail Roshal, Martin S Tallman, David A Knorr

Open access · greenAbstract readCase Reports
In one paragraph

Article in Journal of hematology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Transient Spontaneous Remission of Acute Myeloid Leukemia with Mutated RUNX1: A Rare Report.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Daniel HelbigDepartment of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, NYC, NY, USA.
Andres E QuesadaDepartment of Pathology, Hematopathology Service, Memorial Sloan Kettering Cancer Center, NYC, NY, USA.
Wenbin XiaoDepartment of Pathology, Hematopathology Service, Memorial Sloan Kettering Cancer Center, NYC, NY, USA.
Mikhail RoshalDepartment of Pathology, Hematopathology Service, Memorial Sloan Kettering Cancer Center, NYC, NY, USA.
Martin S TallmanDepartment of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, NYC, NY, USA.
David A KnorrDepartment of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, NYC, NY, USA.
Memorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Although rare, spontaneous remission (SR) of acute myeloid leukemia (AML) has been reported in the literature, the underlying mechanisms driving remission remain unknown. However, it is most commonly associated with a preceding severe infection. We present a case of a 40-year-old man with no past medical history who presented to our hospital with severe left hip pain and fevers and was found to have AML. Chemotherapy was delayed because the patient required extensive debridement and fasciotomy of his left hip and a prolonged course of antibiotics. After his acute illness had stabilized, a repeat bone marrow biopsy was performed which showed no abnormal myeloid blasts and resolution of his original cytogenetic and molecular abnormalities. At the time of this writing, our patient remains in remission with undetectable minimal residual disease (MRD), now 14 months from his initial diagnosis of AML.

Indexed as

AMLMinimal residual diseaseSpontaneous remission

Identifiers

PMID32362981
PMCPMC7188378
OpenAlexW3017522974

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.