Evidence map›Paper›PMID 32362948›Full record

ReviewBeilstein journal of organic chemistry2020

Combining enyne metathesis with long-established organic transformations: a powerful strategy for the sustainable synthesis of bioactive molecules.

Valerian Dragutan, Ileana Dragutan, Albert Demonceau, Lionel Delaude

Abstract readReview
In one paragraph

Review in Beilstein journal of organic chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Synthesis of mixed musksRSC advances · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Valerian DragutanInstitute of Organic Chemistry of the Romanian Academy, Bucharest, 060023, Romania.
Ileana DragutanInstitute of Organic Chemistry of the Romanian Academy, Bucharest, 060023, Romania.
Albert DemonceauLaboratory of Catalysis, Institut de Chimie (B6a), Allée du six Août 13, Université de Liège, 4000 Liège, Belgium.
Lionel DelaudeLaboratory of Catalysis, Institut de Chimie (B6a), Allée du six Août 13, Université de Liège, 4000 Liège, Belgium.ORCID https://orcid.org/0000-0002-1134-2992

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This account surveys the current progress on the application of intra- and intermolecular enyne metathesis as main key steps in the synthesis of challenging structural motifs and stereochemistries found in bioactive compounds. Special emphasis is placed on ruthenium catalysts as promoters of enyne metathesis to build the desired 1,3-dienic units. The advantageous association of this approach with name reactions like Grignard, Wittig, Diels-Alder, Suzuki-Miyaura, Heck cross-coupling, etc. is illustrated. Examples unveil the generality of such tandem reactions in providing not only the intricate structures of known, in vivo effective substances but also for designing chemically modified analogs as valid alternatives for further therapeutic agents.

Indexed as

bioactive compoundsenyne metathesisring-closing metathesisruthenium catalyststandem reactions

Identifiers

PMID32362948
PMCPMC7176922

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.