Evidence map›Paper›PMID 32362893›Full record

ArticleFrontiers in immunology2020

A Signaling Pathway to Mediate the Combined Immunomodulation of Acetylcholine and Enkephalin in Oyster

Zhaoqun Liu, Zhi Zhou, Lingling Wang, Yukun Zhang, Yanan Zong, Yan Zheng, Meijia Li, Weilin Wang, Linsheng Song

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Zhaoqun LiuLiaoning Key Laboratory of Marine Animal Immunology, Dalian Ocean University, Dalian, China.
Zhi ZhouState Key Laboratory of Marine Resource Utilization in South China Sea, Hainan University, Haikou, China.
Lingling WangLiaoning Key Laboratory of Marine Animal Immunology, Dalian Ocean University, Dalian, China.
Yukun ZhangLiaoning Key Laboratory of Marine Animal Immunology, Dalian Ocean University, Dalian, China.
Yanan ZongLiaoning Key Laboratory of Marine Animal Immunology, Dalian Ocean University, Dalian, China.
Yan ZhengLiaoning Key Laboratory of Marine Animal Immunology, Dalian Ocean University, Dalian, China.
Meijia LiLiaoning Key Laboratory of Marine Animal Immunology, Dalian Ocean University, Dalian, China.
Weilin WangLiaoning Key Laboratory of Marine Animal Immunology, Dalian Ocean University, Dalian, China.
Linsheng SongLiaoning Key Laboratory of Marine Animal Immunology, Dalian Ocean University, Dalian, China.
Dalian Ocean University · CNQingdao National Laboratory for Marine Science and Technology · CNHainan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Molluscs have evolved a primitive but complete neuroendocrine-immune (NEI) system with a vast array of neurotransmitters to conduct both humoral and cellular immunomodulation. Previous studies have illustrated the immune functions of several key neurotransmitters. However, the combined effects of multiple neurotransmitters and the signaling pathway to mediate such immunomodulation have not been well-understood. In the present study, iTRAQ and LC-ESI-MS/MS approaches were employed to investigate the combined immunomodulation functions of two crucial neurotransmitters, acetylcholine (ACh), and [Met

Indexed as

Signal TransductionAcetylcholineAnimalsApoptosisCrassostreaEnkephalinsHemocytesImmunomodulationNeurosecretory SystemsProteomeSuperoxide DismutaseAcetylcholineEnkephalinsProteomeSuperoxide DismutaseCrassostrea gigashemocyteimmune regulationneurotransmittersignaling pathway

Identifiers

PMID32362893
PMCPMC7180215
OpenAlexW3016571455

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.