Evidence map›Paper›PMID 32362708›Full record

ArticleProceedings of SPIE--the International Society for Optical Engineering2020

Generative modeling for label-free glomerular modeling and classification.

Brendon Lutnick, Brandon Ginley, Kuang-Yu Jen, Wen Dong, Pinaki Sarder

Abstract read
In one paragraph

Article in Proceedings of SPIE--the International Society for Optical Engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. AI applications in renal pathology.Kidney international · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Brendon LutnickDepartment of Pathology and Anatomical Sciences, SUNY Buffalo.
Brandon GinleyDepartment of Pathology and Anatomical Sciences, SUNY Buffalo.
Kuang-Yu JenDepartment of Pathology, University of California at Davis.
Wen DongDepartment of Computer Science and Engineering, SUNY Buffalo.
Pinaki SarderDepartment of Pathology and Anatomical Sciences, SUNY Buffalo.

Funding

Coordinating and Bioinformatics Unit for the MMPC/DiaCompU24DK076169 · NIDDK · AUGUSTA UNIVERSITY · PI MCINDOE, RICHARD A. · 2006 to 2018
$42.4M
Chronic Kidney Disease (CKD) Biomarkers Consortium Data Coordinating CenterU01DK103225 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI SCHRAUBEN, SARAH JEANNE · 2014 to 2020
$5.5M
Computational Imaging of Renal Structures for Diagnosing DiabeticNephropathyR01DK114485 · NIDDK · UNIVERSITY OF FLORIDA · PI Michael Thomas Eadon, Avi Z Rosenberg · 2018 to 2026
$4.7M
NIDDK NIH HHS R01 DK114485NIDDK NIH HHS U01 DK103225NIDDK NIH HHS U24 DK076169
6 · The paper itself

Abstract

Generative modeling using GANs has gained traction in machine learning literature, as training does not require labeled datasets. This is perfect for applications in biological datasets, where large labeled datasets are often difficult and expensive to acquire. However, generative models offer no easy way to encode real images into feature-sets, something that is desirable for network explainability and may yield potentially informative image features. For this reason, we test a VAE-GAN architecture for label-free modeling of glomerular structural features. We show that this network can generate realistic looking synthetic images, and be used to interpolate between images. To prove the biological relevance of the network encodings, we classify small-labeled sets of encoded glomeruli by biopsy Tervaert class and for the presence of sclerosis, obtaining a Cohen's kappa values of 0.87 and 0.78 respectfully.

Indexed as

generative adversarial networkglomeruliUnsupervised data-miningvariational autoencoder

Identifiers

PMID32362708
PMCPMC7194217

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.