Evidence map›Paper›PMID 32362644›Full record

ArticleThe Indian journal of medical research

Lopinavir/ritonavir combination therapy amongst symptomatic coronavirus disease 2019 patients in India: Protocol for restricted public health emergency use.

Tarun Bhatnagar, Manoj V Murhekar, Manish Soneja, Nivedita Gupta, Sidhartha Giri, Naveet Wig, Raman Gangakhedkar

Open access · diamondAbstract read
In one paragraph

Article in The Indian journal of medical research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 1 synthesis or guideline pooled it, 110 citations in OpenAlex.

  1. Pooled it
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  13. COVID-19 treatment in children: A systematic review and meta-analysis.Journal of family medicine and primary care · 2021
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  20. Immunologic markers, vasculitis-associated autoantibodies, and complement levels in patients with COVID-19.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Tarun BhatnagarSchool of Public Health, ICMR-National Institute of Epidemiology, Chennai, Tamil Nadu, India.
Manoj V MurhekarICMR-National Institute of Epidemiology, Chennai, Tamil Nadu, India.
Manish SonejaDepartment of Medicine, All India Institute of Medical Sciences, New Delhi, India.
Nivedita GuptaDivision of Epidemiology & Communicable Diseases, Indian Council of Medical Research, New Delhi, India.
Sidhartha GiriDivision of Epidemiology & Communicable Diseases, Indian Council of Medical Research, New Delhi, India.
Naveet WigDepartment of Medicine, All India Institute of Medical Sciences, New Delhi, India.
Raman GangakhedkarDivision of Epidemiology & Communicable Diseases, Indian Council of Medical Research, New Delhi, India.
Indian Council of Medical Research · INAll India Institute of Medical Sciences · INNational Institute of Epidemiology · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As of February 29, 2020, more than 85,000 cases of coronavirus disease 2019 (COVID-19) have been reported from China and 53 other countries with 2,924 deaths. On January 30, 2020, the first laboratory-confirmed case of COVID was reported from Kerala, India. In view of the earlier evidence about effectiveness of repurposed lopinavir/ritonavir against severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) coronavirus (CoV), as well as preliminary docking studies conducted by the ICMR-National Institute of Virology, Pune, the Central Drugs Standard Control Organization approved the restricted public health use of lopinavir/ritonavir combination amongst symptomatic COVID-19 patients detected in the country. Hospitalized adult patients with laboratory-confirmed SARS-CoV-2 infection with any one of the following criteria will be eligible to receive lopinavir/ritonavir for 14 days after obtaining written informed consent: (i) respiratory distress with respiratory rate ≥22/min or SpO

Indexed as

Eligibility DeterminationAntiviral AgentsBetacoronavirusCoronavirus InfectionsCOVID-19COVID-19 Drug TreatmentDrug CombinationsEmergenciesGuidelines as TopicHumansIndiaLopinavirPandemicsPneumonia, ViralRitonavirSARS-CoV-2Antiviral AgentsDrug CombinationsLopinavirlopinavir-ritonavir drug combinationRitonavirCoronavirus disease 2019COVID-19lopinavir/ritonavirsevere acute respiratory syndrome coronavirus 2treatment outcome

Identifiers

PMID32362644
PMCPMC7288773
OpenAlexW3011000723

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.