ArticleSchizophrenia research2021
Persistent negative symptoms in youth at clinical high risk for psychosis: A longitudinal study.
Article in Schizophrenia research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
- Elevated defeatist performance beliefs predict state increases in negative symptoms in daily life in clinical high-risk for psychosis youth: implications for mobile health treatments.European archives of psychiatry and clinical neuroscience · 2026Article
- Longitudinal Trajectories of Clinical Features in Community Youth With Recurrent Psychosis Spectrum Symptoms: Findings From the Philadelphia Neurodevelopmental Cohort.Schizophrenia bulletin · 2025Article
- Digital phenotyping evidence for the reduced positivity offset as a mechanism underlying anhedonia among individuals at clinical high-risk for psychosis.Schizophrenia research · 2025Article
- Core beliefs in psychosis: a systematic review and meta-analysis.Schizophrenia (Heidelberg, Germany) · 2025Review
- Longitudinal Trajectories of Premorbid Social and Academic Adjustment in Youth at Clinical High Risk for Psychosis: Implications for Conversion.Schizophrenia bulletin · 2024Article
- Persistent negative symptoms in young people at clinical high risk of psychosis treated with an Italian early intervention program: a longitudinal study.European archives of psychiatry and clinical neuroscience · 2024Article
- Psychosis superspectrum I: Nosology, etiology, and lifespan development.Molecular psychiatry · 2024Review
- Heterogeneity of clinical symptomatology in pediatric patients at clinical high risk for psychosis.BMC research notes · 2024Article
- Negative Symptom Inventory-Self-Report (NSI-SR): Initial development and validation.Schizophrenia research · 2023Article
- Negative Symptom Trajectories in Individuals at Clinical High Risk for Psychosis: Differences Based on Deficit Syndrome, Persistence, and Transition Status.Schizophrenia bulletin open · 2023Article
- Repeated intermittent administration of (R)-ketamine during juvenile and adolescent stages prevents schizophrenia-relevant phenotypes in adult offspring after maternal immune activation: a role of TrkB signaling.European archives of psychiatry and clinical neuroscience · 2022Article
- A redux of schizophrenia research in 2021.Schizophrenia research · 2022Article
- Twelve-Month Cognitive Trajectories in Individuals at Ultra-High Risk for Psychosis: A Latent Class Analysis.Schizophrenia bulletin open · 2022Article
- Multimodal prognosis of negative symptom severity in individuals at increased risk of developing psychosis.Translational psychiatry · 2021Article
- Perceived stress influences anhedonia and social functioning in a community sample enriched for psychosis-risk.Journal of psychiatric research · 2021Article
- Deconstructing Negative Symptoms in Individuals at Clinical High-Risk for Psychosis: Evidence for Volitional and Diminished Emotionality Subgroups That Predict Clinical Presentation and Functional Outcome.Schizophrenia bulletin · 2021Article
- Transdiagnostic Dimensions of Psychiatric Comorbidity in Individuals at Clinical High Risk for Psychosis: A Preliminary Study Informed by HiTOP.Frontiers in psychiatry · 2020Article
- Alexithymia as a Bridge Between Negative Affect and Schizotypy: A Cross-Sectional Network Model.Clinical psychology & psychotherapyArticle
Corrections and comments
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Authors and funding
14 authors at 9 institutions in 2 countries.
Funding
Abstract
backgroundSeverity of negative symptoms has been associated with poor functioning, cognitive deficits, and defeatist beliefs in schizophrenia patients. However, one area that remains understudied is persistent negative symptoms (PNS). Negative symptoms, including PNS, have been observed in those at clinical high-risk (CHR) for psychosis. The aim of this study was to determine if PNS were associated with functioning, neurocognition, and defeatist beliefs in a CHR sample.
methodCHR participants (n = 764) were recruited for the North American Prodrome Longitudinal Study. Negative symptoms were rated on the Scale of Psychosis-risk Symptoms. Generalized linear mixed models for repeated measures were used to examine changes over time between and within groups (PNS vs non-PNS).
resultsThe PNS group (n = 67) had significant deficits in functioning at baseline, 6, 12, 18, and 24-months compared to the non-PNS group (n = 673). Functioning improved over time in the non-PNS group, while functioning in the PNS group remained relatively stable and poor over a two-year period. A consistent trend emerged demonstrating higher defeatist beliefs in the PNS group; however, this result was lost when controlling for persistent depressive symptoms. There were no significant differences between the groups on neurocognition, social cognition, and transition to psychosis.
conclusionsPNS exist in youth at CHR for psychosis, resulting in significant and persistent functional impairment, which remains when controlling for persistent depressive symptoms. PNS remain even in CHR youth who do not transition to psychosis. Thus, PNS may represent an unmet therapeutic need in CHR populations for which there are currently no effective treatments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.