ArticleHypertension (Dallas, Tex. : 1979)2020
Subclinical Systolic and Diastolic Dysfunction Is Evident in Youth With Elevated Blood Pressure.
Article in Hypertension (Dallas, Tex. : 1979), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Elevated Blood Pressure and Cardiac Mechanics in Children and Adolescents: A Systematic Review and Meta-Analysis.American journal of hypertension · 2025Pooled it
- N-of-1 Trials vs. Usual Care in Children With Hypertension: A Pilot Randomized Clinical Trial.American journal of hypertension · 2023Trial
- Ambulatory blood pressure variability in prediction of target organ injury: the SHIP AHOY study.Pediatric nephrology (Berlin, Germany) · 2026Article
- Hypertension control and its association with left ventricular hypertrophy in children and young people on dialysis: a longitudinal study.Pediatric nephrology (Berlin, Germany) · 2026Article
- Early life factors, blood pressure percentile trajectories, and elevated blood pressure in children.Pediatric research · 2026Article
- Long-term outcomes in adults born preterm with symptomatic patent ductus arteriosus.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Admission blood pressure percentiles and in-hospital mortality in pediatric heart failure: a multicenter retrospective cohort study.World journal of pediatrics : WJP · 2026Article
- The prevention of adult cardiovascular disease must begin in childhood: evidence and imperative.Nature reviews. Cardiology · 2026Review
- Pediatric Ambulatory Blood Pressure Patterns and Cardiovascular Risk.Current hypertension reports · 2026Review
- Association of Cardiovascular Health and Genetic Risk for Left Ventricular Mass with Left Ventricular Structure, Function, and Incident Cardiovascular Outcomes.medRxiv : the preprint server for health sciences · 2026Article
- The Japanese Society of Hypertension Guidelines for the management of elevated blood pressure and hypertension 2025 (JSH2025).Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Cardiovascular Assessments in Children and Adolescents With Hypertension.Reviews in cardiovascular medicine · 2025Review
- Youth Blood Pressure and Target Organ Injury Markers: The SHIP AHOY Study.Hypertension (Dallas, Tex. : 1979) · 2025Article
- Assessing early left ventricular remodeling in pediatric hypertension: A study using transthoracic echocardiography combined with two-dimensional speckle tracking echocardiography in an immature rabbit model.Pediatric discovery · 2025Article
- Systolic Blood Pressure, Cardiovascular Health, and Neurocognition in Adolescents.Hypertension (Dallas, Tex. : 1979) · 2024Article
- Hypertension and Cardiovascular Risk Among Children with Chronic Kidney Disease.Current hypertension reports · 2024Review
- Hypertension and Left Ventricular Strain in Pediatric Chronic Kidney Disease.Hypertension (Dallas, Tex. : 1979) · 2024Article
- Medication fill duration in pediatric hypertension: adherence, blood pressure control, and disparities.Pediatric nephrology (Berlin, Germany) · 2024Article
- Mild renal dysfunction causes aggravated cardiac damage in type 2 diabetic patients: a comprehensive echocardiography study.Journal of medical ultrasonics (2001) · 2024Article
- Associations between long-term averages of metabolic parameters in adulthood and cardiac structure and function in later life.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Observational
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Authors and funding
16 authors at 12 institutions in 1 country.
Funding
Abstract
Hypertension is associated with cardiovascular events in adults. Subclinical changes to left ventricular strain and diastolic function have been found before development of decreased left ventricular ejection fraction and cardiovascular events. Our objective was to study effects of blood pressure (BP) on ventricular function in youth across the BP spectrum. Vital signs and labs were obtained in 346 participants aged 11 to 19 years who had BP categorized as low-risk (N=144; systolic BP <75th percentile), mid-risk (N=83; systolic BP ≥80th and <90th percentile), and high-risk (N=119; systolic BP ≥90th percentile). Echocardiography was performed to assess left ventricular strain and diastolic function. Differences between groups were analyzed by ANOVA. General linear models were constructed to determine independent predictors of systolic and diastolic function. Mid-risk and high-risk participants had greater adiposity and more adverse metabolic labs (lower HDL [high-density lipoprotein], higher glucose, and higher insulin) than the low-risk group. Mid-risk and high-risk participants had significantly lower left ventricular ejection fraction and peak global longitudinal strain than the low-risk group (both
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.