Evidence map›Paper›PMID 32362193›Full record

ArticleExpert review of anti-infective therapy2020

Quadruple therapy for asymptomatic COVID-19 infection patients.

Ling Wang, Xiaopeng Xu, Junshan Ruan, Saijin Lin, Jinhua Jiang, Hong Ye

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Expert review of anti-infective therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. [Current Status of Research on COVID-19 Patients With Concomitant Hyperglycemia and the Management Strategies of Hyperglycemia].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2024
    Review
  3. Article
  4. Review
  5. Review
  6. Inhibition of drug-metabolizing enzymes by Qingfei Paidu decoction: Implication of herb-drug interactions in COVID-19 pharmacotherapy.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2021
    Article
  7. Article
  8. Impact of the COVID-19 pandemic on pediatricians' clinical activity in Cameroon.Archives de pediatrie : organe officiel de la Societe francaise de pediatrie · 2020
    Article
  9. Article
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ling WangShengli Clinical Medical College of Fujian Medical University , Fuzhou, Fujian, China.
Xiaopeng XuNanping Center for Disease Control and Prevention , Nanping, Fujian, China.
Junshan RuanShengli Clinical Medical College of Fujian Medical University , Fuzhou, Fujian, China.
Saijin LinDepartment of Infectious Disease, The First Hospital of Nanping , Nanping, Fujian, China.
Jinhua JiangSongxi County Hospital , Songxi County, Nanping, Fujian, China.
Hong YeShengli Clinical Medical College of Fujian Medical University , Fuzhou, Fujian, China.
Fujian Provincial Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe novel coronavirus (COVID-19) is currently in epidemic stage. After large-scale interpersonal infection, asymptomatic patients appear. Whether asymptomatic patients are contagious or not and whether they need medication are the arguments among clinical experts. AREAS COVERED: This paper reports a special asymptomatic couple with COVID-19, of which the male patient is an intercity bus driver but has not induced confirmed infection of his 188 passengers. The patients were treated with four combinations of lopinavir/ritonavir tablets, arbidol tablets, Lianhuaqingwen granules, and recombinant human interferon-α2b (IFN-α2b) injection via aerosol. Their clinical characteristics and medication were summarized and analyzed. EXPERT OPINION: The two asymptomatic patients far away from Wuhan did not seem to be highly contagious. They improved obviously, after treatment with the quadruple therapy, but the effective drug is still unknown. It should be noted that lopinavir/ritonavir tablets have many drug interactions and are the most likely drugs to cause hyperlipidemia and hyperglycemia in these two patients. IFN-α2b is more effective in the early stage of virus infection. Arbidol instruction dose may not be sufficient to inhibit the novel coronavirus

Indexed as

Asymptomatic InfectionsBetacoronavirusCoronavirus InfectionsCOVID-19COVID-19 Drug TreatmentDrug Therapy, CombinationFemaleHumansIndolesInterferon-alphaInterferon alpha-2LopinavirMaleMiddle AgedPandemicsPneumonia, ViralIndolesInterferon-alphaInterferon alpha-2Interferon-alpha2bLopinavirRitonavirSulfidesumifenoviradverse drug reactionarbidolasymptomaticCOVID-19IFN-αlopinavirritonavir

Identifiers

PMID32362193
PMCPMC7212541
OpenAlexW3023797333

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.