ReviewPrenatal diagnosis2020
Fetal brain and placental programming in maternal obesity: A review of human and animal model studies.
Review in Prenatal diagnosis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- A Systematic Patent Review (2008-2023) for Treatment in Pregnancy.Current medicinal chemistry · 2024Pooled it
- Effects of parental overweight and obesity on offspring's mental health: A meta-analysis of observational studies.PloS one · 2022Pooled it
- The relationship between maternal adiposity during pregnancy and toddler ADHD symptoms is mediated by gestational inflammation.Brain, behavior, and immunity · 2026Article
- Beyond Deterministic Fetal Programming: Intrauterine Exposures and the Multifactorial Origins of Adiposity.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Review
- Maternal metformin treatment in obese pregnant dams normalizes neonatal sensory-motor reflexes.Molecular and cellular pediatrics · 2026Article
- The placental tryptophan pathway across gestation: implications for pregnancy outcomes.Human reproduction update · 2026Review
- Maternal pre-pregnancy BMI and neurodevelopmental outcomes in children aged 18-36 months: a nationwide cohort study in Korea.Scientific reports · 2026Article
- Maternal obesity induces activator protein 1-mediated inflammatory response to impair embryonic neurogenesis.The Journal of physiology · 2026Article
- Maternal obesity decreases offspring lifespan.Molecular metabolism · 2026Article
- Developmental Impact of Maternal Immune Activation on the Fetal Immune System and Lung.European journal of immunology · 2026Review
- Maternal polycystic ovarian syndrome and offspring psychopathology and neurodevelopment.Human reproduction (Oxford, England) · 2025Review
- Hypoxia in extravillous trophoblasts links maternal obesity and offspring neurobehavior.iScience · 2025Article
- Sex-specific white matter alterations in children exposed to high pregestational BMI.Obesity (Silver Spring, Md.) · 2025Article
- Prenatal maternal diabetes, comorbidities, and risk for neurodevelopmental impairment in the first two years.Pediatric research · 2025Article
- Impact of maternal prepregnancy body mass index on neonatal outcomes following extremely preterm birth.Obesity (Silver Spring, Md.) · 2025Article
- The consequences of ultra-processed foods on brain development during prenatal, adolescent and adult stages.Frontiers in public health · 2025Review
- Neuroactive steroids in the programming of neurodevelopment: implications of maternal obesity.Frontiers in endocrinology · 2025Review
- Hofbauer cells and fetal brain microglia share transcriptional profiles and responses to maternal diet-induced obesity.Cell reports · 2024Article
- Serotonin Transporter-dependent Histone Serotonylation in Placenta Contributes to the Neurodevelopmental Transcriptome.Journal of molecular biology · 2024Article
- Long-term impact of maternal obesity on the gliovascular unit and ephrin signaling in the hippocampus of adult offspring.Journal of neuroinflammation · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Both human epidemiologic and animal model studies demonstrate that prenatal and lactational exposure to maternal obesity and high-fat diet are associated with adverse neurodevelopmental outcomes in offspring. Neurodevelopmental outcomes described in offspring of obese women include cognitive impairment, autism spectrum disorder (ASD), attention deficit hyperactivity disorder, anxiety and depression, disordered eating, and propensity for reward-driven behavior, among others. This review synthesizes human and animal data linking maternal obesity and high-fat diet consumption to abnormal fetal brain development, and neurodevelopmental and psychiatric morbidity in offspring. It highlights key mechanisms by which maternal obesity and maternal diet impact fetal and offspring development, and sex differences in offspring programming. In addition, we review placental effects of maternal obesity, and the role the placenta might play as an indicator vs mediator of fetal programming.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.