ArticleJournal of child psychology and psychiatry, and allied disciplines2020
Genome-wide DNA methylation patterns associated with sleep and mental health in children: a population-based study.
Article in Journal of child psychology and psychiatry, and allied disciplines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Emerging trends and hot spots of sleep and genetic research: a bibliometric analysis of publications from 2002 to 2022 in the field.Frontiers in neurology · 2023Pooled it
- Longitudinal associations of DNA methylation and sleep in children: a meta-analysis.Clinical epigenetics · 2022Pooled it
- Epigenetic Evidence Implies Disturbed Proteostasis and Potentially Protein Aggregation in Suicidality.Biomolecules · 2026Review
- Shared genetic architecture between Parkinson's disease and self-reported sleep-related traits implicates theSleep advances : a journal of the Sleep Research Society · 2026Article
- Childhood adversity and adolescent epigenetic age acceleration: the role of adolescent sleep health.Sleep advances : a journal of the Sleep Research Society · 2025Article
- Sleep Problems and Autism Impairments in a Large Community Sample of Children and Adolescents.Child psychiatry and human development · 2024Article
- Childhood Adversity and Adolescent Epigenetic Age Acceleration: The Role of Adolescent Sleep Health.medRxiv : the preprint server for health sciences · 2024Article
- A Longitudinal Study of Stress During Pregnancy, Children's Sleep and Polygenic Risk for Poor Sleep in the General Pediatric Population.Research on child and adolescent psychopathology · 2023Article
- Mediating effects of DNA methylation in the association between sleep quality and infertility among women of childbearing age.BMC public health · 2023Article
- Objective and subjective measures of sleep initiation are differentially associated with DNA methylation in adolescents.Clinical epigenetics · 2023Article
- Investigating the Role of BDNF in Insomnia: Current Insights.Nature and science of sleep · 2023Review
- Epigenetics and ADHD: Reflections on Current Knowledge, Research Priorities and Translational Potential.Molecular diagnosis & therapy · 2022Article
- Sleep and mental health in childhood: a multi-method study in the general pediatric population.Child and adolescent psychiatry and mental health · 2022Article
- Genome-wide DNA methylation patterns associated with general psychopathology in children.Journal of psychiatric research · 2021Article
- The regulation mechanisms and the Lamarckian inheritance property of DNA methylation in animals.Mammalian genome : official journal of the International Mammalian Genome Society · 2021Review
- Heritability of Sleep and Its Disorders in Childhood and Adolescence.Current sleep medicine reports · 2021Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundDNA methylation (DNAm) has been implicated in the biology of sleep. Yet, how DNAm patterns across the genome relate to different sleep outcomes, and whether these associations overlap with mental health is currently unknown. Here, we investigated associations of DNAm with sleep and mental health in a pediatric population.
methodsThis cross-sectional study included 465 10-year-old children (51.3% female) from the Generation R Study. Genome-wide DNAm levels were measured using the Illumina 450K array (peripheral blood). Sleep problems were assessed from self-report and mental health outcomes from maternal questionnaires. Wrist actigraphy was used in 188 11-year-old children to calculate sleep duration and midpoint sleep. Weighted gene co-expression network analysis was used to identify highly comethylated DNAm 'modules', which were tested for associations with sleep and mental health outcomes.
resultsWe identified 64 DNAm modules, one of which associated with sleep duration after covariate and multiple testing adjustment. This module included CpG sites spanning 9 genes on chromosome 17, including MAPT - a key regulator of Tau proteins in the brain involved in neuronal function - as well as genes previously implicated in sleep duration. Follow-up analyses suggested that DNAm variation in this region is under considerable genetic control and shows strong blood-brain concordance. DNAm modules associated with sleep did not overlap with those associated with mental health.
conclusionsWe identified one DNAm region associated with sleep duration, including genes previously reported by recent GWAS studies. Further research is warranted to examine the functional role of this region and its longitudinal association with sleep.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.