Evidence map›Paper›PMID 32361925›Full record

ArticleThe international journal of cardiovascular imaging2020

Comparative effectiveness of coronary artery stenosis and atherosclerotic plaque burden assessment for predicting 30-day revascularization and 2-year major adverse cardiac events.

Satoru Kishi, Tiago A Magalhães, Rodrigo J Cerci, Elke Zimmermann, Matthew B Matheson, Andrea Vavere, Yutaka Tanami, Pieter H Kitslaar, Richard T George, Jeffrey Brinker and 12 more

Registry-linked trialOpen access · greenAbstract readComparative StudyMulticenter Study
PubMed Publisher
In one paragraph

Article in The international journal of cardiovascular imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00934037 (Multi Center Combined Non-invasive Coronary Angiography and Myocardial Perfusion Imaging Using 320-Detector Computed Tomography), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00934037 phase3completednot on this map

Multi Center Combined Non-invasive Coronary Angiography and Myocardial Perfusion Imaging Using 320-Detector Computed Tomography

TypeinterventionalSponsorJohns Hopkins UniversityRan2009 to 2017Enrolled444ConditionsArterial Occlusive Diseases, Coronary Disease, Heart Diseases, Myocardial IschemiaArms320 Volume Detector Computed Tomography, Other: Multidetector Computed Tomography - 320 detectors
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. International journal of general medicine · 2024
    Article
  3. Article
  4. Introduction topical issue on CT plaque burden.The international journal of cardiovascular imaging · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 15 institutions in 6 countries.

Satoru KishiDepartment of Medicine/ Diabetology, Mitsui Memorial Hospital, Tokyo, Japan.
Tiago A MagalhãesFederal University of Paraná, Hospital de Clínicas (CHC-UFPR), Curitiba, Brazil.
Rodrigo J CerciQuanta Diagnostico Nuclear, Curitiba, Brazil.
Elke ZimmermannDepartment of Radiology, Charité, Berlin, Germany.
Matthew B MathesonDepartment of Epidemiology, Johns Hopkins University, Baltimore, MD, USA.
Andrea VavereDepartment of Medicine, Johns Hopkins University, Baltimore, USA.
Yutaka TanamiDepartment of Radiology, Keio University, Tokyo, Japan.
Pieter H KitslaarLeiden University Medical Center/Medis Medical Imaging Systems, Leiden, The Netherlands.
Richard T GeorgeDepartment of Medicine, Johns Hopkins University, Baltimore, USA.
Jeffrey BrinkerDepartment of Medicine, Johns Hopkins University, Baltimore, USA.
Julie M MillerDepartment of Medicine, Johns Hopkins University, Baltimore, USA.
Melvin E ClouseiDepartment of Radiology, Beth Israel Deaconess Medical Center, Boston, USA.
Pedro A LemosHeart Institute (InCor), University of Sao Paulo, São Paulo, Brazil.
Hiroyuki NiinumaDepartment of Medicine, Division of Cardiology, St. Luke's Hospital, Tokyo, Japan.
Johan H C ReiberLeiden University Medical Center/Medis Medical Imaging Systems, Leiden, The Netherlands.
Klaus F KofoedDepartment of Medicine, Division of Cardiology, Rigshospitalet, Copenhagen, Denmark.
Carlos E RochitteHeart Institute (InCor), University of Sao Paulo, São Paulo, Brazil.
Frank J RybickiDepartment of Radiology, University of Cincinnati, Cincinnati, USA.
Marcelo F Di CarliDepartment of Radiology, Brigham and Women's Hosptial, Boston, MA, USA.
Christopher CoxDepartment of Epidemiology, Johns Hopkins University, Baltimore, MD, USA.
Joao A C LimaDepartment of Medicine, Johns Hopkins University, Baltimore, USA.
Armin Arbab-ZadehDepartment of Medicine, Johns Hopkins University, Baltimore, USA. azadeh1@jhmi.edu.
Johns Hopkins University · USJohns Hopkins Medicine · USUniversidade de São Paulo · BRBeth Israel Deaconess Medical Center · USBrigham and Women's Hospital · USCentre for Medical Systems Biology · NLCharité - Universitätsmedizin Berlin · DEJohns Hopkins Hospital · USKeio University · JPLeiden University Medical Center · NLMitsui Memorial Hospital · JPRigshospitalet · DKSt. Luke's International Hospital · JPUniversidade Federal do Paraná · BRUniversity of Cincinnati · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo provide comparative prognostic information of coronary atherosclerotic plaque volume and stenosis assessment in patients with suspected coronary artery disease (CAD).

methodsWe followed 372 patients with suspected or known CAD enrolled in the CORE320 study for 2 years after baseline 320-detector row cardiac CT scanning and invasive quantitative coronary angiography (QCA). CT images were analyzed for coronary calcium scanning (CACS), semi-automatically derived total percent atheroma volume (PAV), segment stenosis score (SSS), in addition to traditional stenosis assessment (≥ 50%) by CT and QCA for (1) 30-day revascularization and (2) major adverse cardiac events (MACE). Area under the receiver operating characteristic curve (AUC) was used to compare accuracy of risk prediction.

resultsSixty percent of patients had obstructive CAD by QCA with 23% undergoing 30-day revascularization and 9% experiencing MACE at 2 years. Most late events (20/32) were revascularization procedures. Prediction of 30-day revascularization was modest (AUC range 0.67-0.78) but improved after excluding patients with known CAD (AUC range 0.73-0.86, p < 0.05 for all). Similarly, prediction of MACE improved after excluding patients with known CAD (AUC range 0.58-0.73 vs. 0.63-0.77). CT metrics of atherosclerosis burden performed overall similarly but stenosis assessment was superior for predicting 30-day revascularization.

conclusionsAngiographic and coronary atherosclerotic plaque metrics perform only modestly well for predicting 30-day revascularization and 2-year MACE in high risk patients but improve after excluding patients with known CAD. Atherosclerotic plaque metrics did not yield incremental value over stenosis assessment for predicting events that predominantly consisted of revascularization procedures. CLINICAL

trial registrationNCT00934037.

Indexed as

Computed Tomography AngiographyCoronary AngiographyMultidetector Computed TomographyPlaque, AtheroscleroticAgedComparative Effectiveness ResearchCoronary Artery DiseaseCoronary StenosisCoronary VesselsDisease ProgressionFemaleHeart Disease Risk FactorsHumansMaleMiddle AgedMyocardial RevascularizationAtherosclerosisCoronary artery diseaseCoronary heart diseaseNoninvasive coronary angiographyPlaque burden

Identifiers

PMID32361925
OpenAlexW3023532451

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.