Evidence map›Paper›PMID 32361903›Full record

ArticleEuropean journal of clinical pharmacology2020

Clinically significant drug-drug interactions between tramadol and CYP3A4 inhibitors: disproportionality analysis in VigiBase® and hypothesis on the underlying mechanism.

Clémence Delafoy, Charles Dolladille, Paul Besnier, Marion Sassier, Joanna Bourgine, Véronique Lelong-Boulouard, Joachim Alexandre, Cyril Guillaume, Sophie Fedrizzi, Basile Chrétien

Abstract readLetter
PubMed Publisher
In one paragraph

Article in European journal of clinical pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Clémence DelafoyDepartment of Pharmacology, Caen University Hospital, F-14000, Caen, France.
Charles DolladilleDepartment of Pharmacology, Caen University Hospital, F-14000, Caen, France.
Paul BesnierDepartment of Pharmacology, Caen University Hospital, F-14000, Caen, France.
Marion SassierDepartment of Pharmacology, Caen University Hospital, F-14000, Caen, France.
Joanna BourgineDepartment of Pharmacology, Caen University Hospital, F-14000, Caen, France.
Véronique Lelong-BoulouardDepartment of Pharmacology, Caen University Hospital, F-14000, Caen, France.
Joachim AlexandreDepartment of Pharmacology, Caen University Hospital, F-14000, Caen, France.
Cyril GuillaumeDepartment of Pain and Palliative care, Caen University Hospital, F-14000, Caen, France.
Sophie FedrizziDepartment of Pharmacology, Caen University Hospital, F-14000, Caen, France.
Basile ChrétienDepartment of Pharmacology, Caen University Hospital, F-14000, Caen, France. chretien-b@chu-caen.fr.ORCID http://orcid.org/0000-0002-7483-2489

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Adverse Drug Reaction Reporting SystemsCytochrome P-450 CYP3ACytochrome P-450 CYP3A InhibitorsDrug InteractionsHumansTramadolCYP3A4 protein, humanCytochrome P-450 CYP3ACytochrome P-450 CYP3A InhibitorsTramadol

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.