ArticleJournal of industrial microbiology & biotechnology2020
Combined mutagenesis and metabolic regulation to enhance D-arabitol production from Candida parapsilosis.
Article in Journal of industrial microbiology & biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 26 citations in OpenAlex.
- Facile production of d-arabinitol from waste cells via artificial in vitro enzymatic cascade.Synthetic and systems biotechnology · 2026Article
- Arabitol production: influence of acid and salt stress on glycerol fermentation by Komagataella pastoris, Scheffersomyces stipitis, and Pichia kluyveri in a batch system.Biotechnology letters · 2025Article
- Comparative Transcriptome Analysis Reveals Key Genes Related to Erythritol Production inInternational journal of molecular sciences · 2025Article
- Comprehensive Transcriptomic Analysis of the IsolatedInternational journal of molecular sciences · 2025Article
- Application of Atmospheric and Room-Temperature Plasma (ARTP) to Microbial Breeding.Current issues in molecular biology · 2023Review
- Isolation of Zygosaccharomyces siamensis kiy1 as a novel arabitol-producing yeast and its arabitol production.AMB Express · 2023Article
- Article
- Nonthermal Plasma Effects on Fungi: Applications, Fungal Responses, and Future Perspectives.International journal of molecular sciences · 2022Review
- Enhanced Biosynthesis ofApplied biochemistry and biotechnology · 2022Article
- Application of Non-Thermal Plasma to Fungal Resources.Journal of fungi (Basel, Switzerland) · 2022Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
D-Arabitol is an important pentitol that is widely used in the food, pharmaceutical and chemical industries. It is mainly produced by yeasts during the biotransformation of glucose. To obtain strains with high D-arabitol production, Candida parapsilosis was mutated using atmospheric and room temperature plasma (ARTP). Among the screened mutants, mutant A6 had the highest yield at 32.92 g/L, a 53.98% increase compared with the original strain (21.38 g/L). Furthermore, metabolic regulators were added to the medium to improve D-arabitol production. Pyrithioxin dihydrochloride increased D-arabitol production by 34.4% by regulating glucose-6-phosphate dehydrogenase, and 4-methylpyrazole increased D-arabitol production by 77.4% compared with the control group by inhibiting alcohol dehydrogenase activity. Amphotericin B and Triton X-100 increased D-arabitol production by 23.8% and 42.2% by improving the membrane permeability and dissolved oxygen content, respectively. This study may provide important implications for obtaining high-yield D-arabitol strains.
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Registered trials
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