ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2021
A Metabolite Composite Score Attenuated a Substantial Portion of the Higher Mortality Risk Associated With Frailty Among Community-Dwelling Older Adults.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Metabolomic Pathways of Inflammation and Mitochondrial Dysfunction Are Related to Worsening Healthy Aging Index and Mortality.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Serum methylmalonic acid concentrations at breast cancer diagnosis significantly correlate with clinical frailty.GeroScience · 2024Article
- Metabolomic characterization of vigor to frailty among community-dwelling older Black and White men and women.GeroScience · 2024Article
- Metabolites as frailty biomarkers in older adults.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Reply to Pan et al.: Whole blood metabolome analysis combined with comprehensive frailty assessment.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Metabolomics-Based Frailty Biomarkers in Older Chinese Adults.Frontiers in medicine · 2021Article
- Physiological Dysregulation, Frailty, and Impacts on Adverse Health and Functional Outcomes.Frontiers in medicine · 2021Article
- Whole Blood Metabolomics in Aging Research.International journal of molecular sciences · 2020Review
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Authors and funding
13 authors at 8 institutions in 2 countries.
Funding
Abstract
backgroundFrailty is more prevalent among black versus white older Americans. We previously identified 37 metabolites associated with the vigor to frailty spectrum using the Scale of Aging Vigor in Epidemiology (SAVE) among older black men from the Health, Aging, and Body Composition (Health ABC) study. Here, we sought to develop a metabolite composite score based on the 37 SAVE-associated metabolites and determine whether the composite score predicts mortality and whether it attenuates the association between frailty and mortality among older black men.
methodsPlasma metabolites were measured using liquid chromatography-mass spectrometry. Most of the 37 metabolites were organic acids/derivatives or lipids. Metabolites were ranked into tertiles: tertiles associated with more vigorous SAVE scores were scored 0, mid-tertiles were scored 1, and tertiles associated with frailer SAVE scores were scored 2. Composite scores were the sum of metabolite tertile scores. We examined mortality associations using Cox regression. Percent attenuation estimated the extent to which metabolites attenuated the association between frailty and mortality.
resultsOne standard deviation frailer SAVE was associated with 30% higher mortality, adjusting for age and site (p = .0002); this association was attenuated by 56% after additionally adjusting for the metabolite composite score. In this model, one standard deviation higher metabolite composite score was associated with 46% higher mortality (p < .0001). Metabolite composite scores also predicted mortality (p = .045) in a validation sample of 120 older adults (40% men, 90% white).
conclusionThese metabolites may provide a deeper characterization of the higher mortality that is associated with frailty among older adults.
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