ReviewCurrent opinion in neurobiology2020
Breaking symmetry - cell polarity signaling pathways in growth cone guidance and synapse formation.
Review in Current opinion in neurobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed.
- Neuronal guidance signaling in neurodegenerative diseases: Key regulators that function at neuron-glia and neuroimmune interfaces.Neural regeneration research · 2026Article
- Nervous system-wide analysis of allScience advances · 2025Article
- Small Extracellular Vesicles Promote Axon Outgrowth by Engaging the Wnt-Planar Cell Polarity Pathway.Cells · 2025Article
- Decoding Epilepsy: Prickle2 and Multifaceted Molecular Pathway Connections.Current pharmaceutical design · 2025Review
- Experience-dependent, sexually dimorphic synaptic connectivity defined by sex-specific cadherin expression.Science advances · 2024Article
- Non-canonical Wnt pathway expression in the developing mouse and human retina.Experimental eye research · 2024Article
- Planar cell polarity proteins mediate ketamine-induced restoration of glutamatergic synapses in prefrontal cortical neurons in a mouse model for chronic stress.Nature communications · 2024Article
- Experience-dependent, sexually dimorphic synaptic connectivity defined by sex-specific cadherin expression.bioRxiv : the preprint server for biology · 2024Article
- G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders.Signal transduction and targeted therapy · 2023Review
- Neuronal guidance genes in health and diseases.Protein & cell · 2023Review
- γ-secretase promotes Drosophila postsynaptic development through the cleavage of a Wnt receptor.Developmental cell · 2022Article
- Fat3 acts through independent cytoskeletal effectors to coordinate asymmetric cell behaviors during polarized circuit assembly.Cell reports · 2022Article
- Microtubule Organization Is Essential for Maintaining Cellular Morphology and Function.Oxidative medicine and cellular longevity · 2022Review
- Different strategies by distinct Wnt-signaling pathways in activating a nuclear transcriptional response.Current topics in developmental biology · 2022Article
- Mutation of the murine Prickle1 (R104Q) causes phenotypes analogous to human symptoms of epilepsy and autism.Experimental neurology · 2022Article
- Wnt-frizzled planar cell polarity signaling in the regulation of cell motility.Current topics in developmental biology · 2022Review
- The mAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Prickle promotes the formation and maintenance of glutamatergic synapses by stabilizing the intercellular planar cell polarity complex.Science advances · 2021Article
- Planar cell polarity signaling components are a direct target of β-amyloid-associated degeneration of glutamatergic synapses.Science advances · 2021Article
- Targeting axon guidance cues for neural circuit repair after spinal cord injury.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Directional and positional information is essential for the diverse neuronal morphology and connectivity during development. The direction of axon growth is critical for building the correct networks among neurons, sometimes from far away. Neuronal synapses are asymmetric cell-cell junctions with distinct presynaptic and postsynaptic structures to convey neural activity in a directional fashion. Recent studies show that some of the key asymmetry is mediated by highly conversed cell polarity signaling pathways. These pathways, planar cell polarity and apical-basal polarity, are not required for the global axon-dendrite polarity. Therefore, the apparent distinct types of morphological asymmetry in the nervous system, growth cone turning and synaptic junctions, are mediated by similar cell polarity signaling mechanisms widely used in cellular and tissue morphogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.