ArticleJournal of magnetic resonance (San Diego, Calif. : 1997)2020
Effects of noise and linewidth on in vivo analysis of glutamate at 3 T.
Article in Journal of magnetic resonance (San Diego, Calif. : 1997), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Simultaneous in vivo detection of spectrally resolved glutamate, glutamine, and glutathione at 3 T with NAA-aspartyl editing and echo-time optimization.Magnetic resonance in medicine · 2026Article
- In Vivo Glx Measurements From GABA-Edited HERMES at 3 T Are Not Consistent With Those From Short-TE PRESS Across Scanners, Brain Regions, Diagnostic and Age Groups.NMR in biomedicine · 2026Article
- Validity and specificity of BOLD effects and their correction inFrontiers in neuroscience · 2024Article
- In vivo magnetic resonance spectroscopy by transverse relaxation encoding with narrowband decoupling.Scientific reports · 2023Article
- Neurochemical correlations in short echo time proton magnetic resonance spectroscopy.NMR in biomedicine · 2023Article
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- Magnetic Field Dependence of Spectral Correlations betweenMetabolites · 2023Article
- Monte Carlo study of metabolite correlations originating from spectral overlap.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2022Article
- Single-Voxel Proton Magnetic Resonance Spectroscopy of the Thalamus in Idiopathic Epileptic Dogs and in Healthy Control Dogs.Frontiers in veterinary science · 2022Article
- PCA denoising and Wiener deconvolution ofMagnetic resonance in medicine · 2021Article
- Comparison of different linear-combination modeling algorithms for short-TE proton spectra.NMR in biomedicine · 2021Article
- Cerebral phosphoester signals measured by 31P magnetic resonance spectroscopy at 3 and 7 Tesla.PloS one · 2021Article
- Local and Interregional Neurochemical Associations Measured by Magnetic Resonance Spectroscopy for Studying Brain Functions and Psychiatric Disorders.Frontiers in psychiatry · 2020Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Magnetic resonance spectroscopy (MRS) can noninvasively detect metabolites in vivo, including glutamate (Glu). However, quantification is known to be affected by the overlaps among metabolite resonance lines and background macromolecule signals. We found that adding a moderate amount of noise or line broadening (2 Hz) caused large variations in concentration of Glu and other metabolites, when determined by LCModel analysis of in vivo short-echo time (TE) spectra. Theses variations were largely attributed to strong spectral baselines in short TE spectra, especially near 2.35 ppm, as well as overlapping metabolite resonance lines. To address this issue, we acquired in vivo data at 3 T using both short-TE and the multiple echo time J-resolved point-resolved spectroscopy (JPRESS) MRS techniques. We found that one-dimensional (1D) JPRESS, by simultaneously fitting the two cross-sections of JPRESS at J = 0 and J = 7.5 Hz, was highly resistant to variations in noise levels and spectral linewidths. Our results demonstrate that LCModel analysis of short-TE data is highly sensitive to variations in noise levels and spectral linewidths and this sensitivity is greatly reduced by 1D JPRESS given its substantially reduced baselines and enhanced spectral resolution.
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Registered trials
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