Evidence map›Paper›PMID 32361089›Full record

Trial reportNuclear medicine and biology

Biodistribution, dosimetry, and temporal signal-to-noise ratio analyses of normal and cancer uptake of [

Robert K Doot, Anthony J Young, Margaret E Daube-Witherspoon, David Alexoff, Kyle J Labban, Hwan Lee, Zehui Wu, Zhihao Zha, Seok R Choi, Karl H Ploessl and 7 more

Open access · greenAbstract readClinical Trial
In one paragraph

Trial report in Nuclear medicine and biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Scientific reports · 2023
    Article
  3. Head-to-head comparison of [European journal of nuclear medicine and molecular imaging · 2023
    Article
  4. [Bioconjugate chemistry · 2021
    Article
  5. Frontiers in oncology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 1 institution in 1 country.

Robert K DootDepartment of Radiology, University of Pennsylvania, Philadelphia, PA 19104, United States of America. Electronic address: robdoot@pennmedicine.upenn.edu.
Anthony J YoungDepartment of Radiology, University of Pennsylvania, Philadelphia, PA 19104, United States of America.
Margaret E Daube-WitherspoonDepartment of Radiology, University of Pennsylvania, Philadelphia, PA 19104, United States of America.
David AlexoffFive Eleven Pharma Inc., Philadelphia, PA 19104, United States of America.
Kyle J LabbanDepartment of Radiology, University of Pennsylvania, Philadelphia, PA 19104, United States of America.
Hwan LeeDepartment of Radiology, University of Pennsylvania, Philadelphia, PA 19104, United States of America.
Zehui WuFive Eleven Pharma Inc., Philadelphia, PA 19104, United States of America.
Zhihao ZhaFive Eleven Pharma Inc., Philadelphia, PA 19104, United States of America.
Seok R ChoiFive Eleven Pharma Inc., Philadelphia, PA 19104, United States of America.
Karl H PloesslFive Eleven Pharma Inc., Philadelphia, PA 19104, United States of America.
Erin K SchubertDepartment of Radiology, University of Pennsylvania, Philadelphia, PA 19104, United States of America.
Hsiaoju LeeDepartment of Radiology, University of Pennsylvania, Philadelphia, PA 19104, United States of America.
Lin ZhuFive Eleven Pharma Inc., Philadelphia, PA 19104, United States of America.
Janet S ReddinDepartment of Radiology, University of Pennsylvania, Philadelphia, PA 19104, United States of America.
Joel S KarpDepartment of Radiology, University of Pennsylvania, Philadelphia, PA 19104, United States of America.
Hank KungFive Eleven Pharma Inc., Philadelphia, PA 19104, United States of America.
Daniel A PrymaDepartment of Radiology, University of Pennsylvania, Philadelphia, PA 19104, United States of America.
University of Pennsylvania · US

Funding

Time-of-Flight PET for Improved Whole-Body ImagingR01CA113941 · NCI · UNIVERSITY OF PENNSYLVANIA · PI JOEL S KARP, Suleman Surti · 2006 to 2026
$9.8M
A low-cost automated Gallium-68 drug preparation device for diagnostic PET imagingR43CA217425 · NCI · FIVE ELEVEN PHARMA, INC. · PI ALEXOFF, DAVID · 2017 to 2017
$225k
Development of novel gallium-68 bisphosphonate for imaging bone metastases in prostate cancerR43CA221580 · NCI · FIVE ELEVEN PHARMA, INC. · PI ALEXOFF, DAVID · 2017 to 2017
$225k
NCI NIH HHS R01 CA113941NCI NIH HHS R43 CA217425NCI NIH HHS R43 CA221580
6 · The paper itself

Abstract

introduction[

methodsSubjects with prostate cancer and known or suspected osseous metastatic disease were enrolled into one of two arms: dosimetry or dynamic. Dosimetry was performed with 6 whole body PET acquisitions and urine collection spanning 3 h; normal organ dosimetry was calculated using OLINDA/EXM. Dynamic imaging included a 60 min acquisition over a site of known or suspected disease followed by two whole body scans. Bootstrapping and subsampling of the acquired list-mode data were conducted to recommend image acquisition parameters for future clinical trials.

resultsUp to 233 MBq (6.3 mCi) of [

conclusionsDosimetry estimates are acceptable and [ ADVANCES IN KNOWLEDGE AND IMPLICATIONS FOR PATIENT CARE: Use of [

Indexed as

Signal-To-Noise RatioAdultAgedBiological TransportEdetic AcidHumansIsotope LabelingMaleMiddle AgedPositron Emission Tomography Computed TomographyProstatic NeoplasmsRadiometrySafetyTissue DistributionEdetic AcidN,N'-bis(2-hydroxy-5-(ethylene-beta-carboxy)benzyl)ethylenediamine N,N'-diacetic acidBisphosphonateBone metastasesGallium-68PETProstate cancer

Identifiers

PMID32361089
PMCPMC7311273
OpenAlexW3017582847

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.