ReviewTranslational research : the journal of laboratory and clinical medicine2020
Frailty and aging in cancer survivors.
Review in Translational research : the journal of laboratory and clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 9 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
70 citing papers in PubMed, 9 syntheses or guidelines pooled it, 114 citations in OpenAlex.
- Frailty and survival of patients with renal cell carcinoma: A meta-analysis.Biomolecules & biomedicine · 2025Pooled it
- The prognostic role of Geriatric 8 in patients with cancer: a meta-analysis and systematic review.The oncologist · 2025Pooled it
- A meta-analysis on the impact of concurrent or pre-existing cancer diagnosis on acute myocardial infarction outcomes.PloS one · 2025Pooled it
- Blood-based biomarkers of frailty in solid tumors: a systematic review.Frontiers in public health · 2023Pooled it
- Frailty and long-term survival of patients with colorectal cancer: a meta-analysis.Aging clinical and experimental research · 2022Pooled it
- The prevalence of frailty among breast cancer patients: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Pooled it
- Genome-wide association studies identify novel genetic loci for epigenetic age acceleration among survivors of childhood cancer.Genome medicine · 2022Pooled it
- Can biomarkers be used to improve diagnosis and prediction of metabolic syndrome in childhood cancer survivors? A systematic review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2021Pooled it
- Impacts of Frailty on Prognosis in Lung Cancer Patients: A Systematic Review and Meta-Analysis.Frontiers in medicine · 2021Pooled it
- Evaluating the role of survivorship care plans in modifying disparities in health status among female cancer survivors in Maryland.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Frailty in older patients with cancer in Vietnam.BMC geriatrics · 2026Observational
- Incidence and Management Trends in Advanced Head and Neck Non-Melanoma Skin Cancer in Ontario.Current oncology (Toronto, Ont.) · 2026Article
- Article
- Review
- Frailty level, cancer history and healthcare utilization among older adults: Results from the US National Health Interview Survey.Asia-Pacific journal of oncology nursing · 2025Article
- Age-appropriate needs-based care in an onco-primary care survivorship program for survivors of childhood, adolescent and young adult, and adult cancers.Journal of cancer survivorship : research and practice · 2025Article
- Frailty as a predictor of mortality in lung cancer survivors: evidence from a nationally representative cohort NHIS 1997-2018.Scientific reports · 2025Article
- Frailty phenotype state transitions among older adults with a history of cancer and diabetes.BMC geriatrics · 2025Article
- Genetic evidence for causal effects of inflammatory protein factors on breast cancer.Discover oncology · 2025Article
- Voices of Survivorship: The Unmet Needs of Italian Cancer Survivors. A Qualitative Study.Cancer medicine · 2025Observational
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
There are over 15 million survivors of cancer in the United States whose rates of frailty, an aging phenotype, range from just under 10% to over 80%. Frailty impacts not only disease survival but also long-term function and quality of life in children, adolescents, and in all adults diagnosed and/or treated for cancer. This review explains frailty as a construct and model of physiologic well-being. It also describes how frailty at diagnosis impacts cancer outcomes in adult populations and enumerates the prevalence of frailty in different populations of cancer survivors. Biological mechanisms responsible for aging and potentially for frailty among individuals with or who have been treated for cancer are discussed. Finally, promising pharmaceutical and lifestyle interventions designed to impact aging rather than a specific disease, tested in other populations, but likely applicable in cancer patients and survivors, are discussed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.