ReviewTranslational research : the journal of laboratory and clinical medicine2020
The gut microbiome and frailty.
Review in Translational research : the journal of laboratory and clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Association of gut microbiome with mobility impairment in the Hispanic Community Health Study/Study of Latinos.NPJ biofilms and microbiomes · 2026Article
- Lipid-derived microbial metabolites at the gut-liver interface: regulation of intestinal barrier function, immune signaling, and metabolic inflammation.Frontiers in physiology · 2026Review
- Associations of dietary intake for gut microbiota with frailty risk and mortality in older adults.Journal of translational medicine · 2025Article
- Metabolic signature of EAT-Lancet diet in relation to risk of frailty: a prospective cohort study.NPJ science of food · 2025Article
- Article
- The association between a dietary index for the gut microbiota and frailty in older adults: emphasising the mediating role of inflammatory indicators.Frontiers in nutrition · 2025Article
- Targeting muscle-vasculature crosstalk in aging through the integrative roles of L-citrulline, leucine, and exercise: focus on muscle metabolism, vascular function, and sarcopenia prevention.Frontiers in nutrition · 2025Review
- Diminished representation of vitamin-B12-producing bacteria in constipated elders with frailty.iScience · 2024Article
- Developing the Common Marmoset as a Translational Geroscience Model to Study the Microbiome and Healthy Aging.Microorganisms · 2024Review
- Fecal Microbiota Transplantation Attenuates Frailty via Gut-Muscle Axis in Old Mice.Aging and disease · 2024Article
- Association of dietary live microbe intake with frailty in US adults: evidence from NHANES.The journal of nutrition, health & aging · 2024Article
- Comparison of the Fecal Bacteriome of HIV-Positive and HIV-Negative Older Adults.Biomedicines · 2023Article
- Intestinal microbial 16S sequencing and LC-MS metabonomic analysis revealed differences between young and old cats.Heliyon · 2023Article
- Review
- The Gut Microbiome and Its Implication in the Mucosal Digestive Disorders.Biomedicines · 2022Review
- Innovations in the veterinary intestinal health field: A patent landscape analysis.One health (Amsterdam, Netherlands) · 2022Article
- Frailty and postoperative urinary tract infection.BMC geriatrics · 2022Article
- The gut microbiome as a modulator of healthy ageing.Nature reviews. Gastroenterology & hepatology · 2022Review
- The Many Ages of Microbiome-Gut-Brain Axis.Nutrients · 2022Article
- Impact of sucroferric oxyhydroxide on the oral and intestinal microbiome in hemodialysis patients.Scientific reports · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The human microbiome is constituted by an extensive network of organisms that lie at the host/environment interface and transduce signals that play vital roles in human health and disease across the lifespan. Frailty is a critical aging-related syndrome marked by diminished physiological reserve and heightened vulnerability to stress, predictive of major adverse clinical outcomes including death. While recent studies suggest the microbiome may impact key pathways critical to frailty pathophysiology, direct evaluation of the microbiome-frailty relationship remains limited. In this article, we review the complex interplay of biological, behavioral, and environmental factors that may influence shifts in gut microbiome composition and function in aging populations and the putative implications of such shifts for progression to frailty. We discuss HIV infection as a key prototype for elucidating the complex pathways via which the microbiome may precipitate frailty. Finally, we review considerations for future research efforts.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.