Evidence map›Paper›PMID 32360744›Full record

ArticleToxicology and applied pharmacology2020

Maternal-fetal disposition of domoic acid following repeated oral dosing during pregnancy in nonhuman primate.

Sara Shum, Jing Jing, Rebekah Petroff, Brenda Crouthamel, Kimberly S Grant, Thomas M Burbacher, Nina Isoherranen

Open access · greenAbstract readRandomized Controlled Trial, Veterinary
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology and applied pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Developmental Exposure to Domoic Acid Disrupts Startle Response Behavior and Circuitry in Zebrafish.Toxicological sciences : an official journal of the Society of Toxicology · 2021
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Sara ShumDepartment of Pharmaceutics, University of Washington, Seattle, Washington, USA.
Jing JingDepartment of Pharmaceutics, University of Washington, Seattle, Washington, USA.
Rebekah PetroffDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, USA.
Brenda CrouthamelDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, USA.
Kimberly S GrantDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, USA; Infant Primate Research Laboratory, Washington National Primate Research Center, Seattle, Washington, USA.
Thomas M BurbacherDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, USA; Center on Human Development and Disability, University of Washington, Seattle, Washington, USA; Infant Primate Research Laboratory, Washington National Primate Research Center, Seattle, Washington, USA.
Nina IsoherranenDepartment of Pharmaceutics, University of Washington, Seattle, Washington, USA; Center on Human Development and Disability, University of Washington, Seattle, Washington, USA. Electronic address: ni2@uw.edu.
University of Washington · USOregon National Primate Research Center · US

Funding

Washington National Primate Research CenterP51OD010425 · OD · UNIVERSITY OF WASHINGTON · PI Mari Ostendorf · 2012 to 2026
$201.8M
XENOBIOTIC BIOTRANSFORMATION AND DISPOSITIONP30ES007033 · NIEHS · UNIVERSITY OF WASHINGTON · PI Sheela Sathyanarayana · 1995 to 2026
$42.5M
Mechanisms of Brain Dysmorphology in MN1 C-Terminal Truncation Syndrome, a Novel Intellectual Developmental Disability Disorder P50HD103524 · NICHD · UNIVERSITY OF WASHINGTON · PI Sandra E Juul · 2020 to 2026
$9.9M
Intellectual and Developmental Disabilities Research CenterU54HD083091 · NICHD · UNIVERSITY OF WASHINGTON · PI GARDEN, GWENN A · 2014 to 2019
$7.9M
Developmental Neurotoxicity of Domoic Acid in a Nonhuman Primate ModelR01ES023043 · NIEHS · UNIVERSITY OF WASHINGTON · PI BURBACHER, THOMAS M · 2014 to 2019
$4.3M
NICHD NIH HHS P50 HD103524NICHD NIH HHS U54 HD083091NIEHS NIH HHS P30 ES007033NIEHS NIH HHS R01 ES023043NIH HHS P51 OD010425
6 · The paper itself

Abstract

Domoic acid (DA) is a marine algal toxin that causes acute and chronic neurotoxicity in animals and humans. Prenatal exposure to DA has been associated with neuronal damage and cognitive and behavioral deficits in juvenile California sea lions, cynomolgus monkeys and rodents. Yet, the toxicokinetics (TK) of DA during pregnancy and the maternal-fetal disposition of DA have not been fully elucidated. In this study, we investigated the TK before, during, and after pregnancy and the maternal-fetal disposition of DA in 22 cynomolgus monkeys following daily oral doses of 0.075 or 0.15 mg/kg/day of DA. The AUC

Indexed as

Kainic AcidMacaca fascicularisMaternal-Fetal ExchangeAmniotic FluidAnimalsDouble-Blind MethodFemaleFetusPlacentaPregnancydomoic acidKainic Acid

Identifiers

PMID32360744
PMCPMC7445014
OpenAlexW3022568781

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.