Evidence map›Paper›PMID 32360728›Full record

ArticleChest2020

Incidence and Risk Model Development for Severe Tachypnea Following Terminal Extubation.

Corey R Fehnel, Miguel Armengol de la Hoz, Leo A Celi, Margaret L Campbell, Khalid Hanafy, Ala Nozari, Douglas B White, Susan L Mitchell

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chest, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 21 citations in OpenAlex.

  1. Palliative extubation in intensive care units: scoping review.Revista da Escola de Enfermagem da U S P · 2026
    Article
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  8. Emotional impact of compassionate extubation on respiratory therapists and nurses: A pilot study.Canadian journal of respiratory therapy : CJRT = Revue canadienne de la therapie respiratoire : RCTR · 2022
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 2 countries.

Corey R FehnelHebrew SeniorLife Hinda and Arthur Marcus Institute for Aging Research, Boston, MA; Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA; Harvard Medical School, Boston, MA. Electronic address: cfehnel@bidmc.harvard.edu.
Miguel Armengol de la HozDivision of Clinical Informatics, Beth Israel Deaconess Medical Center, Boston, MA; Harvard Medical School, Boston, MA; Laboratory for Computational Physiology, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA; Biomedical Engineering and Telemedicine Group, Biomedical Technology Centre CTB, ETSI Telecomunicación, Universidad Politécnica de Madrid, Madrid, Spain.
Leo A CeliDepartment of Medicine, Division of Pulmonary and Critical Care, Beth Israel Deaconess Medical Center, Boston, MA; Massachusetts Institute of Technology, Cambridge, MA.
Margaret L CampbellWayne State College of Nursing, Detroit, MI.
Khalid HanafyDepartment of Neurology, Beth Israel Deaconess Medical Center, Boston, MA; Harvard Medical School, Boston, MA.
Ala NozariDepartment of Medicine, Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, MA; Harvard Medical School, Boston, MA.
Douglas B WhiteDepartment of Critical Care, University of Pittsburgh Medical Center, Pittsburgh, PA.
Susan L MitchellHebrew SeniorLife Hinda and Arthur Marcus Institute for Aging Research, Boston, MA; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA; Harvard Medical School, Boston, MA.
Beth Israel Deaconess Medical Center · USHarvard University · USHebrew SeniorLife · USMassachusetts Institute of Technology · USUniversidad Politécnica de Madrid · ESUniversity of Pittsburgh Medical Center · USWayne State College · US

Funding

Critical Care Informatics: Ethical considerations around the use and sharing of health-related dataR01EB017205 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI CELI, LEO ANTHONY G, MARK, ROGER GREENWOOD · 2014 to 2021
$3.8M
A Trial to Improve Surrogate Decision-Making for Critically Ill Older AdultsR01AG045176 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WHITE, DOUGLAS B · 2013 to 2017
$2.9M
Modulation of the TLR4-Lyn interaction in SAHR01NS109174 · NINDS · ROWAN UNIVERSITY · PI HANAFY, KHALID A. · 2019 to 2023
$2.4M
Midcareer Mentoring Award for Patient-Oriented Research in AgingK24AG033640 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI MITCHELL, SUSAN L · 2009 to 2018
$1.8M
Intensive Palliative Care: Improving the Process of Palliative Ventilator Withdrawal Among Critically Ill Older AdultsK23AG066929 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI FEHNEL, COREY R · 2020 to 2024
$972k
Mentored Patient Oriented Research in Improving Surrogate Decision Making for Patients with Advanced Respiratory FailureK24HL148314 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Douglas B White · 2019 to 2026
$944k
Critical Care InformaticsR56EB017205 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI CELI, LEO ANTHONY G, GHASSEMI, MARZYEH · 2018 to 2023
$783k
The Clinical Course and Outcomes of Older Stroke Patients with Feeding TubesR03AG060186 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI FEHNEL, COREY R · 2018 to 2019
$245k
NHLBI NIH HHS K24 HL148314NIA NIH HHS K23 AG066929NIA NIH HHS K24 AG033640NIA NIH HHS R01 AG045176NIA NIH HHS R03 AG060186NIBIB NIH HHS R01 EB017205NIBIB NIH HHS R56 EB017205NINDS NIH HHS R01 NS109174
6 · The paper itself

Abstract

backgroundPalliative ventilator withdrawal (PVW) in the ICU is a common occurrence. RESEARCH QUESTION: The goal of this study was to measure the rate of severe tachypnea as a proxy for dyspnea and to identify characteristics associated with episodes of tachypnea. STUDY DESIGN AND

methodsThis study assessed a retrospective cohort of ICU patients from 2008 to 2012 mechanically ventilated at a single academic medical center who underwent PVW. The primary outcome of at least one episode of severe tachypnea (respiratory rate > 30 breaths/min) within 6 h after PVW was measured by using detailed physiologic and medical record data. Multivariable logistic regression was used to examine the association between patient and treatment characteristics with the occurrence of a severe episode of tachypnea post extubation.

resultsAmong 822 patients undergoing PVW, 19% and 30% had an episode of severe tachypnea during the 1-h and 6-h postextubation period, respectively. Within 1 h postextubation, patients with the following characteristics were more likely to experience tachypnea: no pre-extubation opiates (adjusted OR [aOR], 2.08; 95% CI, 1.03-4.19), lung injury (aOR, 3.33; 95% CI, 2.19-5.04), Glasgow Coma Scale score > 8 (aOR, 2.21; 95% CI, 1.30-3.77), and no postextubation opiates (aOR, 1.90; 95% CI, 1.19-3.00).

interpretationUp to one-third of ICU patients undergoing PVW experience severe tachypnea. Administration of pre-extubation opiates (anticipatory dosing) represents a key modifiable factor that may reduce poor symptom control.

Indexed as

AdolescentAdultAgedAged, 80 and overAirway ExtubationCohort StudiesFemaleHumansIncidenceMaleMiddle AgedModels, StatisticalRetrospective StudiesRisk AssessmentSeverity of Illness IndexTachypneadyspneaend of lifepalliative careventilator withdrawal

Identifiers

PMID32360728
PMCPMC7545486
OpenAlexW3023112859

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.