ArticleInternational journal of cardiology2020
Recreational marathon running does not cause exercise-induced left ventricular hypertrabeculation.
Article in International journal of cardiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 15 citations in OpenAlex.
- Left ventricular excessive trabeculation: pathophysiology, diagnostic challenges, and prognostic significance.Heart failure reviews · 2026Review
- Left Ventricular Hypertrabeculation (LVHT) in Athletes: A Negligible Finding?Medicina (Kaunas, Lithuania) · 2024Article
- Left ventricular trabeculation in Hominidae: divergence of the human cardiac phenotype.Communications biology · 2024Article
- Excessive Trabeculation of the Left Ventricle: JACC: Cardiovascular Imaging Expert Panel Paper.JACC. Cardiovascular imaging · 2023Review
- Equal force generation potential of trabecular and compact wall ventricular cardiomyocytes.iScience · 2022Article
- Higher spatial resolution improves the interpretation of the extent of ventricular trabeculation.Journal of anatomy · 2022Article
- The Underrepresentation of Females in Studies Assessing the Impact of High-Dose Exercise on Cardiovascular Outcomes: a Scoping Review.Sports medicine - open · 2021Article
Corrections and comments
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Authors and funding
17 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundMarathon running in novices represents a natural experiment of short-term cardiovascular remodeling in response to running training. We examine whether this stimulus can produce exercise-induced left ventricular (LV) trabeculation.
methodsSixty-eight novice marathon runners aged 29.5 ± 3.2 years had indices of LV trabeculation measured by echocardiography and cardiac magnetic resonance imaging 6 months before and 2 weeks after the 2016 London Marathon race, in a prospective longitudinal study.
resultsAfter 17 weeks unsupervised marathon training, indices of LV trabeculation were essentially unchanged. Despite satisfactory inter-observer agreement in most methods of trabeculation measurement, criteria defining abnormally hypertrabeculated cases were discordant with each other. LV hypertrabeculation was a frequent finding in young, healthy individuals with no subject demonstrating clear evidence of a cardiomyopathy.
conclusionTraining for a first marathon does not induce LV trabeculation. It remains unclear whether prolonged, high-dose exercise can create de novo trabeculation or expose concealed trabeculation. Applying cut off values from published LV noncompaction cardiomyopathy criteria to young, healthy individuals risks over-diagnosis.
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