ArticleAmerican journal of ophthalmology2020
Vision Loss in Optic Disc Drusen Correlates With Increased Macular Vessel Diameter and Flux and Reduced Peripapillary Vascular Density.
Article in American journal of ophthalmology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 24 citations in OpenAlex.
- Prelaminar hyperreflective lines in non-arteritic anterior ischaemic optic neuropathy.Eye (London, England) · 2026Article
- Risk stratification of visual field progression in optic disc drusen with and without glaucoma.International ophthalmology · 2026Article
- Multimodal OCT/OCT-A Risk Stratification in Optic Disc Drusen: Drusen Height, Peripapillary Perfusion, and Visual Field Slope Identify Fast Progressors.Diagnostics (Basel, Switzerland) · 2026Article
- A Systematic Review of Optic Disc Drusen in the Modern Imaging Era: Structure-Function Correlates, Diagnostic Performance, and NAION Co-Occurrence.Diagnostics (Basel, Switzerland) · 2025Review
- The Framework of Quantifying Biomarkers of OCT and OCTA Images in Retinal Diseases.Sensors (Basel, Switzerland) · 2024Article
- Dimension-based quantification of aging-associated cerebral microvasculature determined by optical coherence tomography and two-photon microscopy.Journal of biophotonics · 2024Article
- An open-source deep learning network AVA-Net for arterial-venous area segmentation in optical coherence tomography angiography.Communications medicine · 2023Article
- Microvascular Changes in Pituitary Adenoma Correlate with Structural Measurements and Visual Field Loss.Neuropsychiatric disease and treatment · 2023Article
- Comparison of Spectral-Domain OCT versus Swept-Source OCT for the Detection of Deep Optic Disc Drusen.Diagnostics (Basel, Switzerland) · 2022Article
- Correlation Between Laser Speckle Flowgraphy and OCT-Derived Retinal and Choroidal Metrics in Healthy Human Eye.Translational vision science & technology · 2022Article
- Multimodal Ophthalmic Imaging of Nonarteritic Anterior Ischemic Optic Neuropathy With and Without Optic Disc Drusen.Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society · 2022Article
- Evaluation of Peripapillary and Macular Vascular Flow Changes with OCT-A in Patients with Superficial Optic Disk Drusen.Sisli Etfal Hastanesi tip bulteni · 2022Article
- Phenotypic Features and Genetic Findings in a Cohort of ItalianJournal of clinical medicine · 2021Article
- Kinetic and static perimetry after 16 years and additional OCT-A analysis in eyes with long-lasting optic disc drusen.PloS one · 2021Article
- Diagnosing Optic Disc Drusen in the Modern Imaging Era: A Practical Approach.Neuro-ophthalmology (Aeolus Press) · 2021Review
- Hypoxia-induced inflammation: Profiling the first 24-hour posthypoxic plasma and central nervous system changes.PloS one · 2021Article
- Topographic Quadrant Analysis of Peripapillary Superficial Microvasculature in Optic Disc Drusen.Frontiers in neurology · 2021Article
- The current clinical role of optical coherence tomography angiography in neuro-ophthalmological diseases.Taiwan journal of ophthalmologyReview
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
purposeTo determine the key optical coherence tomography (OCT) and OCT angiography (OCTA) parameters that correlate with visual field loss in optic disc drusen (ODD).
designRetrospective cross-sectional study.
methodsSingle academic center. Seventeen patients with ODD (29 eyes) and 35 age-matched controls (53 eyes). Static perimetry, OCT, and OCTA imaging of optic disc and macula. Static perimetry, OCT, and OCTA measurements.
resultsWe investigated the relationship between static perimetry and 14 OCT/OCTA measurements in patients with ODD vs age-matched controls and found 5 key measurements that most correlated with visual field loss included: peripapillary retinal nerve fiber layer (RNFL), macular ganglion cell complex (GCC), peripapillary vessel area density (VAD), macular vessel diameter (VD), and flux. Hierarchical clustering of these 5 measurements vs all clinical characteristics revealed 3 distinct clusters. ODD and control eyes with no visual field loss (mean deviation [MD] > -2.0 dB) had high RNFL and GCC, and low macular VD and flux. ODD eyes with mild visual field loss (MD -2.0 to -5.0 dB) had high RNFL, GCC, and increased macular VD and flux. ODD eyes with moderate/severe visual field loss (MD < -5.0 dB) had decreased RNFL, GCC, peripapillary VAD, and increased macular VD and flux.
conclusionsOCT and OCTA provided objective measurements that can help predict visual field loss in ODD. Our data suggest that increased macular flow may be an early biomarker of visual field loss in ODD, while decreased peripapillary vessel density and RNFL thickness are late biomarkers of visual field loss in ODD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.