Evidence map›Paper›PMID 32359808›Full record

ReviewKidney international2020

Machine learning, the kidney, and genotype-phenotype analysis.

Rachel S G Sealfon, Laura H Mariani, Matthias Kretzler, Olga G Troyanskaya

Abstract readReview
In one paragraph

Review in Kidney international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Metabolomics: A useful tool for ischemic stroke research.Journal of pharmaceutical analysis · 2023
    Review
  9. Article
  10. Review
  11. Article
  12. Advances in proteomic profiling of pediatric kidney diseases.Pediatric nephrology (Berlin, Germany) · 2022
    Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rachel S G SealfonCenter for Computational Biology, Flatiron Institute, Simons Foundation, New York, New York, USA.
Laura H MarianiDivision of Nephrology, University of Michigan, Ann Arbor, Michigan, USA.
Matthias KretzlerDivision of Nephrology, University of Michigan, Ann Arbor, Michigan, USA. Electronic address: kretzler@umich.edu.
Olga G TroyanskayaCenter for Computational Biology, Flatiron Institute, Simons Foundation, New York, New York, USA; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, USA; Department of Computer Science, Princeton University, Princeton, New Jersey, USA. Electronic address: ogt@cs.princeton.edu.

Funding

Central Hub for Kidney Precision MedicineU24DK114886 · NIDDK · UNIVERSITY OF WASHINGTON · PI Jonathan Himmelfarb, Matthias Kretzler · 2022 to 2026
$21.1M
ConProject-002U2CDK114886 · NIDDK · UNIVERSITY OF WASHINGTON · PI HIMMELFARB, JONATHAN · 2017 to 2021
$21.0M
CureGNU24DK100845 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CRYSTAL A. GADEGBEKU, Laura H Mariani · 2019 to 2026
$12.1M
Tissue Chip Data to the Microphysiology Systems Database (MPS-Db) Supplement to A Microphysiological System for Kidney Disease Modeling and Drug Efficacy TestingUH3TR002158 · NCATS · UNIVERSITY OF WASHINGTON · PI HIMMELFARB, JONATHAN · 2019 to 2021
$4.2M
PREcision Medicine through IntErrogation of Rna in the kidnEy (PREMIERE)UG3DK114907 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HACOHEN, NIR, HODGIN, JEFFREY BENTON · 2017 to 2018
$925k
Cleveland Precision Medicine Chronic Kidney Disease CohortUH3DK114908 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI O'TOOLE, JOHN F., POGGIO, EMILIO DANIEL · 2019 to 2021
$900k
Integrative Molecular Epidemiology Approach to Identify Nephrotic Syndrome SubgroupsK08DK115891 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MARIANI, LAURA H · 2018 to 2021
$678k
NCATS NIH HHS UH3 TR002158NIDDK NIH HHS K08 DK115891NIDDK NIH HHS U24 DK100845NIDDK NIH HHS U24 DK114886NIDDK NIH HHS U2C DK114886NIDDK NIH HHS UH3 DK114908
6 · The paper itself

Abstract

With biomedical research transitioning into data-rich science, machine learning provides a powerful toolkit for extracting knowledge from large-scale biological data sets. The increasing availability of comprehensive kidney omics compendia (transcriptomics, proteomics, metabolomics, and genome sequencing), as well as other data modalities such as electronic health records, digital nephropathology repositories, and radiology renal images, makes machine learning approaches increasingly essential for analyzing human kidney data sets. Here, we discuss how machine learning approaches can be applied to the study of kidney disease, with a particular focus on how they can be used for understanding the relationship between genotype and phenotype.

Indexed as

Computational BiologyMachine LearningGenotypeHumansKidneyPhenotypedeep learninggenotypemachine learning

Identifiers

PMID32359808
PMCPMC8048707

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.