ArticlePoultry science2020
Influence of meat and bone meal, phytase, and antibiotics on broiler chickens challenged with subclinical necrotic enteritis: 2. intestinal permeability, organ weights, hematology, intestinal morphology, and jejunal gene expression.
Article in Poultry science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- Modulation of the intestinal microbiota: impact on productive performance and intestinal health in broiler breeder hens.Poultry science · 2026Review
- Optimized amino acid ratios in reduced crude protein diets sustain broiler performance, gut health, and resilience to necrotic enteritis.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- Effects of Superdose phytase and acidifier supplementation in a phosphorus-deficient diet on growth performance, carcass characteristics, Cecal microbiota, and intestinal and liver morphology in broiler chickens.Veterinary and animal science · 2026Article
- Article
- Effects of Fish Bone Meal Supplementation on Growth Performance, Blood Immunity, Intestinal Morphology, and Gut Microbiota in Laying Hens.Animals : an open access journal from MDPI · 2025Article
- Effects of AddingAnimals : an open access journal from MDPI · 2024Article
- Growth Performance and Immunity of Broilers Fed Sorghum-Soybean Meal Diets Supplemented with Phytases and Β-Mannanases.Animals : an open access journal from MDPI · 2024Article
- Negative consequences of reduced protein diets supplemented with synthetic amino acids for performance, intestinal barrier function, and caecal microbiota composition of broiler chickens.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2023Article
- Evaluation of gene expression related to immunity, apoptosis, and gut integrity that underlies3 Biotech · 2023Article
- Article
- In ovo injection of cinnamon or clove alters the physiology and growth of broilers in a hot tropical environment.Translational animal science · 2023Article
- The Growth Performance, Nutrient Digestibility, Gut Bacteria and Bone Strength of Broilers Offered Alternative, Sustainable Diets Varying in Nutrient Specification and Phytase Dose.Animals : an open access journal from MDPI · 2022Article
- Bacillus amyloliquefaciens BLCC1-0238 Alone or in Combination with Mannan-Oligosaccharides Alleviates Subclinical Necrotic Enteritis in Broilers.Probiotics and antimicrobial proteins · 2022Article
- Current experimental models, assessment and dietary modulations of intestinal permeability in broiler chickens.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2021Review
- Differential expression of intestinal genes in necrotic enteritis challenged broiler chickens with 2 different Clostridium perfringens strains.Poultry science · 2021Article
- Comparison of overfeeding effects on gut physiology and microbiota in two goose breeds.Poultry science · 2021Article
- Modulations of genes related to gut integrity, apoptosis, and immunity underlie the beneficial effects ofJournal of animal science and biotechnology · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Undigested proteins entering the hindgut may favor the proliferation of Clostridium perfringens. Using phytase to eliminate the need for meat and bone meal (MBM) as a P source may reduce potential infection with C. perfringens. A study was conducted to determine the impact of MBM, phytase, and antibiotics (AB) on intestinal permeability and morphology, organ weights, and jejunal gene expression in Ross 308 chickens challenged with subclinical necrotic enteritis (NE). Male Ross 308-day-old chicks (672 each) were randomly allocated to 8 treatments with 6 replicate pens each housing 14 birds. A 2 × 2 × 2 factorial arrangement of treatments was used: MBM (no or yes); AB (no or yes-Zn bacitracin 100 in S and 50 ppm in G/F and salinomycin Na 60 ppm in all phases); phytase (500 or 1,500 FTU/kg, both using 500 FTU matrix values) using wheat-SBM-canola meal diets. Birds were challenged with Eimeria spp on day 9, and C. perfringens strain EHE-NE18 on day 14 and 15. An AB × MBM interaction (P < 0.05) was detected for relative gizzard weight (with contents) being lower in birds fed MBM and AB compared to those fed MBM and no AB. A MBM × AB interaction (P > 0.01) was detected for lymphocyte counts being lower with MBM and AB compared to MBM without AB. A phytase × AB interaction (P < 0.05) was observed for villi length being increased with high phytase and no AB compared to with AB. Inclusion of MBM increased (P < 0.05) blood FICT-d concentration, whereas AB decreased it (P < 0.05). Antibiotics increased RBC (P < 0.05), Hgb (P < 0.05), and PCV (P < 0.05) and expression of Ca-binding protein, CALB1 (P > 0.05). Inclusion of MBM decreased expression of MUC2 (P < 0.05). Results indicate that dietary MBM has a detrimental effect on gut health of broilers but this may be counteracted using AB.
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